3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-[6-bromo-3-(3-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide

Base Information

Chemical Name:3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-[6-bromo-3-(3-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide
CAS No.:514830-39-8
Molecular Formula:C₂₅H₂₀BrClN₄O₄
Molecular Weight:555.815
Hs Code.:

3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid <i>N</i>'-[6-bromo-3-(3-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide

Synonyms:3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-[6-bromo-3-(3-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide

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Chemical Property of 3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-[6-bromo-3-(3-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide

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Technology Process of 3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-[6-bromo-3-(3-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide

There total 4 articles about 3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-[6-bromo-3-(3-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 121-33-5,8014-42-4
vanillin

: 514830-26-3
acetic acid N'-[6-bromo-3-(3-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide

: 514830-39-8
3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-[6-bromo-3-(3-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide

Guidance literature:: With sodium hydroxide; In methanol; Heating;

Reference yield:

: 450401-31-7
6-bromo-3-(3-chloro-phenyl)-2-methyl-3H-quinazolin-4-one

: 514830-39-8
3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-[6-bromo-3-(3-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / Br₂ / acetic acid / 0 - 5 °C

2: 35 percent / hydrazine hydrate / ethanol / Heating

3: 60 percent / CHCl₃ / 0 - 5 °C

4: 25 percent / aq. NaOH / methanol / Heating

With sodium hydroxide; bromine; hydrazine hydrate; In methanol; ethanol; chloroform; acetic acid;

Reference yield:

: 514830-18-3
6-bromo-2-bromomethyl-3-(3-chloro-phenyl)-3H-quinazolin-4-one

: 514830-39-8
3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-[6-bromo-3-(3-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / hydrazine hydrate / ethanol / Heating

2: 60 percent / CHCl₃ / 0 - 5 °C

3: 25 percent / aq. NaOH / methanol / Heating

With sodium hydroxide; hydrazine hydrate; In methanol; ethanol; chloroform;