Technology Process of 4-((4-fluoro-2-(phenylethynyl)phenyl)sulfinyl)-N,N-dimethylaniline
There total 4 articles about 4-((4-fluoro-2-(phenylethynyl)phenyl)sulfinyl)-N,N-dimethylaniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenylacetylene;
With
isopropyl magnesium chloride - lithium chloride complex;
at 60 ℃;
for 0.0833333h;
Inert atmosphere;
With
zinc(II) chloride;
In
tetrahydrofuran;
at 25 ℃;
Inert atmosphere;
C14H13FINOS;
With
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
at 50 ℃;
for 2h;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ol801431z
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere
1.2: 25 °C / Inert atmosphere
2.1: isopropylmagnesium bromide / tetrahydrofuran / 0.08 h / 60 °C / Inert atmosphere
2.2: 25 °C / Inert atmosphere
2.3: 2 h / 50 °C / Inert atmosphere
With
2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; isopropylmagnesium bromide;
In
tetrahydrofuran;
DOI:10.1002/chem.201003657
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / -20 - 25 °C / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / -20 °C / Inert atmosphere
3.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere
3.2: 25 °C / Inert atmosphere
4.1: isopropylmagnesium bromide / tetrahydrofuran / 0.08 h / 60 °C / Inert atmosphere
4.2: 25 °C / Inert atmosphere
4.3: 2 h / 50 °C / Inert atmosphere
With
2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; isopropylmagnesium bromide; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1002/chem.201003657
