6-bromo-2-tert-butyldimethylsilanyloxymethyl-3-methoxymethoxybenzylic alcohol

Base Information

Chemical Name:6-bromo-2-tert-butyldimethylsilanyloxymethyl-3-methoxymethoxybenzylic alcohol
CAS No.:565176-49-0
Molecular Formula:C₁₆H₂₇BrO₄Si
Molecular Weight:391.377
Hs Code.:

Synonyms:6-bromo-2-tert-butyldimethylsilanyloxymethyl-3-methoxymethoxybenzylic alcohol

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Chemical Property of 6-bromo-2-tert-butyldimethylsilanyloxymethyl-3-methoxymethoxybenzylic alcohol

Chemical Property:

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Technology Process of 6-bromo-2-tert-butyldimethylsilanyloxymethyl-3-methoxymethoxybenzylic alcohol

There total 3 articles about 6-bromo-2-tert-butyldimethylsilanyloxymethyl-3-methoxymethoxybenzylic alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 565176-48-9
4-bromo-2,3-bis(hydroxymethyl)methoxy-methoxybenzene

: 565176-49-0
6-bromo-2-tert-butyldimethylsilanyloxymethyl-3-methoxymethoxybenzylic alcohol

: [3-bromo-2-(tert-butyl-dimethyl-silanyloxymethyl)-6-methoxymethoxy-phenyl]-methanol

Guidance literature:: With triethylamine; In dichloromethane; at -15 - 20 ℃;
DOI:10.1016/S0040-4020(03)00427-7

Reference yield:

: acetic acid 2,3-diacetoxy-6-bromophenylester

: 565176-49-0
6-bromo-2-tert-butyldimethylsilanyloxymethyl-3-methoxymethoxybenzylic alcohol

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / LiOH / dioxane; H₂O / 1 h / 20 °C

2: 31 percent / NaH / dimethylformamide / 1 h / 20 °C

3: 51 percent / triethylamine / CH₂Cl₂ / -15 - 20 °C

With lithium hydroxide; sodium hydride; triethylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)00427-7

Reference yield:

: 565176-47-8
4-bromo-2,3-bis(hydroxymethyl)phenol

: 565176-49-0
6-bromo-2-tert-butyldimethylsilanyloxymethyl-3-methoxymethoxybenzylic alcohol

Guidance literature:: Multi-step reaction with 2 steps

1: 31 percent / NaH / dimethylformamide / 1 h / 20 °C

2: 51 percent / triethylamine / CH₂Cl₂ / -15 - 20 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)00427-7