1-(benzyloxymethyl)-4-(2-chloroethyl)-2-(4-methoxybenzyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

Base Information

• Chemical Name: 1-(benzyloxymethyl)-4-(2-chloroethyl)-2-(4-methoxybenzyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
• CAS No.: 1127249-86-8
• Molecular Formula: C₂₄H₂₆ClNO₅
• Molecular Weight: 443.927
• Mol file: 1127249-86-8.mol

Synonyms:1-(benzyloxymethyl)-4-(2-chloroethyl)-2-(4-methoxybenzyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

Chemical Property of 1-(benzyloxymethyl)-4-(2-chloroethyl)-2-(4-methoxybenzyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(benzyloxymethyl)-4-(2-chloroethyl)-2-(4-methoxybenzyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

There total 12 articles about 1-(benzyloxymethyl)-4-(2-chloroethyl)-2-(4-methoxybenzyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H28ClNO6 (1239897-04-1) → 1-(benzyloxymethyl)-4-(2-chloroethyl)-2-(4-methoxybenzyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione (1127249-86-8) + C24H26ClNO5

Guidance literature:

With 4-pyrrolidin-1-ylpyridine; methanesulfonyl chloride; In toluene; at -10 - -5 ℃; for 1.5h; optical yield given as %ee; Inert atmosphere;

DOI:10.1039/c0cc00607f

Reference yield:

C24H28ClNO6 (1239897-04-1) → 1-(benzyloxymethyl)-4-(2-chloroethyl)-2-(4-methoxybenzyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione (1127249-86-8) + C24H26ClNO5 + C24H26ClNO5

Guidance literature:

With 4-pyrrolidin-1-ylpyridine; methanesulfonyl chloride; In toluene; at -10 - -5 ℃; for 3.5h; optical yield given as %ee; Inert atmosphere;

DOI:10.1039/c0cc00607f

Reference yield:

C24H28ClNO6 (1239897-04-1) → 1-(benzyloxymethyl)-4-(2-chloroethyl)-2-(4-methoxybenzyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione (1127249-86-8) + C24H26ClNO5 + C24H26ClNO5 (1239897-03-0)

Guidance literature:

With 4-pyrrolidin-1-ylpyridine; methanesulfonyl chloride; In toluene; at -10 - -5 ℃; for 3.5h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/jo101638r

upstream raw materials:

C₂₄H₂₈ClNO₆

C₂₇H₃₂ClNO₆

C₂₇H₃₂ClNO₆

(R)-O-benzyl-N-PMB serine