(S)-3-{(8R,13R)-8-Hydroxy-13-methoxymethoxy-13-[(2R,5R)-5-((R)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Base Information

Chemical Name:(S)-3-{(8R,13R)-8-Hydroxy-13-methoxymethoxy-13-[(2R,5R)-5-((R)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one
CAS No.:184435-87-8
Molecular Formula:C₄₅H₇₈O₈S
Molecular Weight:779.176
Hs Code.:

(S)-3-{(8R,13R)-8-Hydroxy-13-methoxymethoxy-13-[(2R,5R)-5-((R)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Synonyms:(S)-3-{(8R,13R)-8-Hydroxy-13-methoxymethoxy-13-[(2R,5R)-5-((R)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

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Chemical Property of (S)-3-{(8R,13R)-8-Hydroxy-13-methoxymethoxy-13-[(2R,5R)-5-((R)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

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Technology Process of (S)-3-{(8R,13R)-8-Hydroxy-13-methoxymethoxy-13-[(2R,5R)-5-((R)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

There total 22 articles about (S)-3-{(8R,13R)-8-Hydroxy-13-methoxymethoxy-13-[(2R,5R)-5-((R)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 184435-85-6
(S)-3-{(8R,13R)-8-Hydroxy-13-methoxymethoxy-13-[(2R,5R)-5-((R)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridec-10-ynyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

: 184435-87-8
(S)-3-{(8R,13R)-8-Hydroxy-13-methoxymethoxy-13-[(2R,5R)-5-((R)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Guidance literature:: With hydrogen; (triphenylphosphine)rhodium; In benzene; for 5h;

Reference yield:

: 57618-47-0
5-benzyloxy-1-pentyne

: 184435-87-8
(S)-3-{(8R,13R)-8-Hydroxy-13-methoxymethoxy-13-[(2R,5R)-5-((R)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 12 steps

1: 1) 1.56 M nBuLi in hexane / 1) THF, -40 deg C then 0 deg C, 40 min, 2) THF, HMPA, 0 deg C, 1 h then 1 h, RT

2: 96 percent / hydrogen / 10percent Pd/C / ethyl acetate / 12 h / Ambient temperature

3: pyridine / ) deg C, 1 h; RT, 5 h

4: 91 percent / NaI, NaHCO₃ / acetone / 8 h

5: 10 0.6 m NaHMDS in toluene / 1) THF, 0 deg C, 30 min, 2) THF, toluene, HMPA, 0 deg C to RT

6: 99 percent / p-TsOH / methanol / 48 h

7: 82 percent / Et₃N, DMAP / CH₂Cl₂ / 12 h

8: Et₃N / -10 °C

9: 55percent aq. HF / acetonitrile / 3 h / 0 °C

10: NaH (60percent in oil) / tetrahydrofuran / 48 h

11: 1) 1.6 m nBuLi in hexane, 2) BF₃*Et₂O / 1) THF, -78 deg C, 30 min, 2) THF, hexane, 20 min, -78 deg C, 3) THF, hexane, ether, 1 h, -78 deg C

12: 99 percent / hydrogen / (triphenylphosphine)rhodium / benzene / 5 h

With pyridine; dmap; n-butyllithium; boron trifluoride diethyl etherate; hydrogen fluoride; hydrogen; sodium hexamethyldisilazane; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; sodium iodide; palladium on activated charcoal; (triphenylphosphine)rhodium; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetone; acetonitrile; benzene;

Reference yield:

: 184435-67-4
(2R,5R,1'S,1''R)-2-(1',2'-dihydroxyethyl)-5-(1''-hydroxytridecyl)tetrahydrofuran

: 184435-87-8
(S)-3-{(8R,13R)-8-Hydroxy-13-methoxymethoxy-13-[(2R,5R)-5-((R)-1-methoxymethoxy-tridecyl)-tetrahydro-furan-2-yl]-tridecyl}-5-methyl-3-phenylsulfanyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 10 steps

1: 95 percent / p-TsOH / 2 h

2: 99 percent / (iPr)2EtN / CH₂Cl₂ / 24 h / Ambient temperature

3: 96 percent / 60percent aq. AcOH / 6 h / 60 °C

4: 97 percent / Et₃N, DMAP / 12 h

5: Et₃N / CH₂Cl₂ / -10 °C

6: 1) nBuNF, 2) 15percent aq. NaOH / 1) THF, 0 deg C, 12 h, 2) THF, 0 deg C, 30 min then RT, 5 h

7: 1) 1.56 M nBuLi in hexane, 2) BF₃*Et₂O / 1) THF, -78 deg C, 20 min, 2) THF, -78 deg C, 30 min, 3) THF, -78 deg C, 2 h

8: 96 percent / (iPr)2EtN / CH₂Cl₂ / 25 h / Ambient temperature

9: 1) 1.6 m nBuLi in hexane, 2) BF₃*Et₂O / 1) THF, -78 deg C, 30 min, 2) THF, hexane, 20 min, -78 deg C, 3) THF, hexane, ether, 1 h, -78 deg C

10: 99 percent / hydrogen / (triphenylphosphine)rhodium / benzene / 5 h

With dmap; sodium hydroxide; n-butyllithium; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; (triphenylphosphine)rhodium; In dichloromethane; benzene;