(S)-tert-butyl 4-(4-(benzyloxycarbonylamino)butanamido)-3-((1R,3R)-3-(4-methoxy-4-oxobutylcarbamoyl)-2,2-dimethylcyclobutyl)butanoate

Base Information

• Chemical Name: (S)-tert-butyl 4-(4-(benzyloxycarbonylamino)butanamido)-3-((1R,3R)-3-(4-methoxy-4-oxobutylcarbamoyl)-2,2-dimethylcyclobutyl)butanoate
• CAS No.: 1234493-11-8
• Molecular Formula: C₃₂H₄₉N₃O₈
• Molecular Weight: 603.756
• Mol file: 1234493-11-8.mol

Synonyms:(S)-tert-butyl 4-(4-(benzyloxycarbonylamino)butanamido)-3-((1R,3R)-3-(4-methoxy-4-oxobutylcarbamoyl)-2,2-dimethylcyclobutyl)butanoate

Chemical Property of (S)-tert-butyl 4-(4-(benzyloxycarbonylamino)butanamido)-3-((1R,3R)-3-(4-methoxy-4-oxobutylcarbamoyl)-2,2-dimethylcyclobutyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 4-(4-(benzyloxycarbonylamino)butanamido)-3-((1R,3R)-3-(4-methoxy-4-oxobutylcarbamoyl)-2,2-dimethylcyclobutyl)butanoate

There total 1 articles about (S)-tert-butyl 4-(4-(benzyloxycarbonylamino)butanamido)-3-((1R,3R)-3-(4-methoxy-4-oxobutylcarbamoyl)-2,2-dimethylcyclobutyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1R,3R)-3-((S)-15,15-dimethyl-3,8,13-trioxo-1-phenyl-2,14-dioxa-4,9-diazahexadecan-11-yl)-2,2-dimethylcyclobutanecarboxylic acid (1234493-10-7) + 4-aminobutyric acid methyl ester trifluoroacetate → (S)-tert-butyl 4-(4-(benzyloxycarbonylamino)butanamido)-3-((1R,3R)-3-(4-methoxy-4-oxobutylcarbamoyl)-2,2-dimethylcyclobutyl)butanoate (1234493-11-8)

Guidance literature:

(1R,3R)-3-((S)-15,15-dimethyl-3,8,13-trioxo-1-phenyl-2,14-dioxa-4,9-diazahexadecan-11-yl)-2,2-dimethylcyclobutanecarboxylic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.0833333h; Inert atmosphere;

4-aminobutyric acid methyl ester trifluoroacetate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol1010664

Reference yield: 100.0%

(S)-tert-butyl 4-(4-(benzyloxycarbonylamino)butanamido)-3-((1R,3R)-3-(4-methoxy-4-oxobutylcarbamoyl)-2,2-dimethylcyclobutyl)butanoate (1234493-11-8) → C28H41N3O8 (1234493-12-9)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ol1010664

upstream raw materials:

(1R,3R)-3-((S)-15,15-dimethyl-3,8,13-trioxo-1-phenyl-2,14-dioxa-4,9-diazahexadecan-11-yl)-2,2-dimethylcyclobutanecarboxylic acid

Downstream raw materials:

C₂₈H₄₁N₃O₈