ethyl (R)-2-[bis(2-methoxyphenyloxy)phosphinyloxy]-2-(4-fluorophenyl)acetate

Base Information

Chemical Name:ethyl (R)-2-[bis(2-methoxyphenyloxy)phosphinyloxy]-2-(4-fluorophenyl)acetate
CAS No.:1282521-64-5
Molecular Formula:C₂₄H₂₄FO₈P
Molecular Weight:490.422
Hs Code.:

Synonyms:ethyl (R)-2-[bis(2-methoxyphenyloxy)phosphinyloxy]-2-(4-fluorophenyl)acetate

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Chemical Property of ethyl (R)-2-[bis(2-methoxyphenyloxy)phosphinyloxy]-2-(4-fluorophenyl)acetate

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Technology Process of ethyl (R)-2-[bis(2-methoxyphenyloxy)phosphinyloxy]-2-(4-fluorophenyl)acetate

There total 6 articles about ethyl (R)-2-[bis(2-methoxyphenyloxy)phosphinyloxy]-2-(4-fluorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1813-94-1
ethyl 4-fluorobenzoylformate

: bis(o-methoxyphenyl) phosphonate

: 1282521-64-5
ethyl (R)-2-[bis(2-methoxyphenyloxy)phosphinyloxy]-2-(4-fluorophenyl)acetate

Guidance literature:: With sodium carbonate; quinidine; In cyclopentyl methyl ether (CPME); at -30 ℃; for 18h; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201007568

Reference yield:

: 1813-94-1
ethyl 4-fluorobenzoylformate

: bis(o-methoxyphenyl) phosphonate

: 1282521-53-2
ethyl (S)-2-[bis(2-methoxyphenyloxy)phosphinyloxy]-2-(4-fluorophenyl)acetate

: 1282521-64-5
ethyl (R)-2-[bis(2-methoxyphenyloxy)phosphinyloxy]-2-(4-fluorophenyl)acetate

Guidance literature:: With sodium carbonate; Quinine; In cyclopentyl methyl ether (CPME); at -30 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201007568

Reference yield:

: 90-05-1
2-methoxy-phenol

: 1282521-64-5
ethyl (R)-2-[bis(2-methoxyphenyloxy)phosphinyloxy]-2-(4-fluorophenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / toluene / 3 h / 0 - 40 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: sodium carbonate; quinidine / cyclopentyl methyl ether (CPME) / 18 h / -30 °C / Inert atmosphere

With pyridine; sodium carbonate; quinidine; In cyclopentyl methyl ether (CPME); toluene; 2.1: phospha-Brook rearrangement;
DOI:10.1002/anie.201007568