5-[2-(4-chlorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Base Information

Chemical Name:5-[2-(4-chlorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
CAS No.:1035695-08-9
Molecular Formula:C₁₄H₁₃ClO₅
Molecular Weight:296.707
Hs Code.:

Synonyms:5-[2-(4-chlorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[2-(4-chlorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

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Technology Process of 5-[2-(4-chlorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

There total 3 articles about 5-[2-(4-chlorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1878-66-6
4-chlorophenylacetic Acid

: 2033-24-1
cycl-isopropylidene malonate

: 1035695-08-9
5-[2-(4-chlorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: 4-chlorophenylacetic Acid; With dmap; pivaloyl chloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.75h; Cooling with ice;

cycl-isopropylidene malonate; In acetonitrile; at 45 ℃;

Reference yield:

: 2033-24-1
cycl-isopropylidene malonate

: 25026-34-0
4-chlorophenacetyl chloride

: 1035695-08-9
5-[2-(4-chlorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jo9822075

Reference yield:

: 1878-66-6
4-chlorophenylacetic Acid

: 1035695-08-9
5-[2-(4-chlorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / toluene

2: pyridine / CH₂Cl₂ / 2 h / 0 - 20 °C

With pyridine; thionyl chloride; In dichloromethane; toluene;
DOI:10.1021/jo9822075