[(1S,3R,4R)-3-(2-Methoxy-ethoxymethoxy)-4-((E)-propenyl)-cyclohexylmethoxymethyl]-benzene

Base Information

Chemical Name:[(1S,3R,4R)-3-(2-Methoxy-ethoxymethoxy)-4-((E)-propenyl)-cyclohexylmethoxymethyl]-benzene
CAS No.:131067-45-3
Molecular Formula:C₂₁H₃₂O₄
Molecular Weight:348.483
Hs Code.:

Synonyms:[(1S,3R,4R)-3-(2-Methoxy-ethoxymethoxy)-4-((E)-propenyl)-cyclohexylmethoxymethyl]-benzene

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Chemical Property of [(1S,3R,4R)-3-(2-Methoxy-ethoxymethoxy)-4-((E)-propenyl)-cyclohexylmethoxymethyl]-benzene

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Technology Process of [(1S,3R,4R)-3-(2-Methoxy-ethoxymethoxy)-4-((E)-propenyl)-cyclohexylmethoxymethyl]-benzene

There total 12 articles about [(1S,3R,4R)-3-(2-Methoxy-ethoxymethoxy)-4-((E)-propenyl)-cyclohexylmethoxymethyl]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 3970-21-6
2-Methoxyethoxymethyl chloride

: 131102-89-1
(1R,2R,5S)-5-Benzyloxymethyl-2-((E)-propenyl)-cyclohexanol

: 131067-45-3
[(1S,3R,4R)-3-(2-Methoxy-ethoxymethoxy)-4-((E)-propenyl)-cyclohexylmethoxymethyl]-benzene

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 48h; Ambient temperature;

Reference yield:

: 76469-08-4
5-octynolic acid

: 131067-45-3
[(1S,3R,4R)-3-(2-Methoxy-ethoxymethoxy)-4-((E)-propenyl)-cyclohexylmethoxymethyl]-benzene

Guidance literature:: Multi-step reaction with 9 steps

1: (COCl)2

2: 1) nBuLi / 1) THF

3: 1) (Me₂Si)2NLi / 1) THF, -78 deg C, 2) THF, -78 to 0 deg C

4: LiAlH₄ / tetrahydrofuran

5: KH / tetrahydrofuran

6: 1) ozone

7: 98 percent / hydrogen, quinoline / 5percent Pd/CaCO₃ / hexane

8: Me₂AlCl / CH₂Cl₂

With quinoline; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; (Me₂Si)2NLi; hydrogen; dimethylaluminum chloride; potassium hydride; ozone; Lindlar's catalyst; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00238a060

Reference yield:

: 100-39-0
benzyl bromide

: 131067-45-3
[(1S,3R,4R)-3-(2-Methoxy-ethoxymethoxy)-4-((E)-propenyl)-cyclohexylmethoxymethyl]-benzene

Guidance literature:: Multi-step reaction with 5 steps

1: KH / tetrahydrofuran

2: 1) ozone

3: 98 percent / hydrogen, quinoline / 5percent Pd/CaCO₃ / hexane

4: Me₂AlCl / CH₂Cl₂

With quinoline; hydrogen; dimethylaluminum chloride; potassium hydride; ozone; Lindlar's catalyst; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00238a060