Technology Process of [(1S,3R,4R)-3-(2-Methoxy-ethoxymethoxy)-4-((E)-propenyl)-cyclohexylmethoxymethyl]-benzene
There total 12 articles about [(1S,3R,4R)-3-(2-Methoxy-ethoxymethoxy)-4-((E)-propenyl)-cyclohexylmethoxymethyl]-benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
for 48h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: (COCl)2
2: 1) nBuLi / 1) THF
3: 1) (Me2Si)2NLi / 1) THF, -78 deg C, 2) THF, -78 to 0 deg C
4: LiAlH4 / tetrahydrofuran
5: KH / tetrahydrofuran
6: 1) ozone
7: 98 percent / hydrogen, quinoline / 5percent Pd/CaCO3 / hexane
8: Me2AlCl / CH2Cl2
With
quinoline; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; (Me2Si)2NLi; hydrogen; dimethylaluminum chloride; potassium hydride; ozone;
Lindlar's catalyst;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00238a060
- Guidance literature:
-
Multi-step reaction with 5 steps
1: KH / tetrahydrofuran
2: 1) ozone
3: 98 percent / hydrogen, quinoline / 5percent Pd/CaCO3 / hexane
4: Me2AlCl / CH2Cl2
With
quinoline; hydrogen; dimethylaluminum chloride; potassium hydride; ozone;
Lindlar's catalyst;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00238a060