(4-Toluenesulphonyl)-<<3-(t-butyldimethylsilyloxy)-5-(methoxymethyl)>-phenyl>-2,2,2-trifluoroethanone Oxime

Base Information

Chemical Name:(4-Toluenesulphonyl)-<<3-(t-butyldimethylsilyloxy)-5-(methoxymethyl)>-phenyl>-2,2,2-trifluoroethanone Oxime
CAS No.:136386-82-8
Molecular Formula:C₂₃H₃₀F₃NO₅SSi
Molecular Weight:517.642
Hs Code.:

Synonyms:(4-Toluenesulphonyl)-<<3-(t-butyldimethylsilyloxy)-5-(methoxymethyl)>-phenyl>-2,2,2-trifluoroethanone Oxime

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Chemical Property of (4-Toluenesulphonyl)-<<3-(t-butyldimethylsilyloxy)-5-(methoxymethyl)>-phenyl>-2,2,2-trifluoroethanone Oxime

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Technology Process of (4-Toluenesulphonyl)-<<3-(t-butyldimethylsilyloxy)-5-(methoxymethyl)>-phenyl>-2,2,2-trifluoroethanone Oxime

There total 5 articles about (4-Toluenesulphonyl)-<<3-(t-butyldimethylsilyloxy)-5-(methoxymethyl)>-phenyl>-2,2,2-trifluoroethanone Oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 136386-81-7
<<3-(t-Butyldimethylsilyloxy)-5-(methoxymethyl)>phenyl>-2,2,2-trifluoroethanone Oxime

: 98-59-9
p-toluenesulfonyl chloride

: 136386-82-8
(4-Toluenesulphonyl)-<<3-(t-butyldimethylsilyloxy)-5-(methoxymethyl)>-phenyl>-2,2,2-trifluoroethanone Oxime

Guidance literature:: With pyridine; for 3.5h; Heating;
DOI:10.1016/S0040-4020(01)80991-1

Reference yield:

: 626-41-5
3,5-dibromophenol

: 136386-82-8
(4-Toluenesulphonyl)-<<3-(t-butyldimethylsilyloxy)-5-(methoxymethyl)>-phenyl>-2,2,2-trifluoroethanone Oxime

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH₂Cl₂ / 1 h / Ambient temperature

2: 1) BuLi / 1) THF, -78 deg C, 0.5 h; 2) THF, -78 deg C, 0.5 h

3: 81 percent / NH₂OH*HCl, pyridine / ethanol / 4 h / Heating

4: 81 percent / pyridine / 3.5 h / Heating

With pyridine; n-butyllithium; hydroxylamine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)80991-1

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 136386-82-8
(4-Toluenesulphonyl)-<<3-(t-butyldimethylsilyloxy)-5-(methoxymethyl)>-phenyl>-2,2,2-trifluoroethanone Oxime

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH₂Cl₂ / 1 h / Ambient temperature

2: 1) BuLi / 1) THF, -78 deg C, 0.5 h; 2) THF, -78 deg C, 0.5 h

3: 81 percent / NH₂OH*HCl, pyridine / ethanol / 4 h / Heating

4: 81 percent / pyridine / 3.5 h / Heating

With pyridine; n-butyllithium; hydroxylamine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)80991-1