2,3,4,6-Tetramethylpyridine

Base Information

• Chemical Name: 2,3,4,6-Tetramethylpyridine
• CAS No.: 20820-82-0
• Molecular Formula: C9H13 N
• Molecular Weight: 135.209
• Hs Code.: 2933399090
• European Community (EC) Number: 244-061-3
• DSSTox Substance ID: DTXSID00174937
• Nikkaji Number: J225.342I
• Wikidata: Q83045124
• Mol file: 20820-82-0.mol

Synonyms:2,3,4,6-Tetramethylpyridine;20820-82-0;Pyridine, 2,3,4,6-tetramethyl-;EINECS 244-061-3;SCHEMBL801989;2,3,4,6-Tetramethyl-pyridin;2,3,4,6-tetramethyl-pyridine;DTXSID00174937

Chemical Property of 2,3,4,6-Tetramethylpyridine

Chemical Property:

• Vapor Pressure: 0.341mmHg at 25°C
• Melting Point: 31.33°C (estimate)
• Refractive Index: 1.5087
• Boiling Point: 206.4°Cat760mmHg
• Flash Point: 74°C
• PSA: 12.89000
• Density: 0.915g/cm³
• LogP: 2.31520
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 135.104799419
• Heavy Atom Count: 10
• Complexity: 111

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=C1C)C)C

Technology Process of 2,3,4,6-Tetramethylpyridine

There total 11 articles about 2,3,4,6-Tetramethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-2-pentanol (6032-29-7,13403-73-1) + acetic anhydride (108-24-7) → 2,3,5,6-tetramethylpyridine (3748-84-3) + 2,6-dimethyllutidine (20820-82-0) + 3-ethyl-2,6-dimethylpyridine (23580-52-1)

Guidance literature:

With ammonium hydroxide; Nafion-H; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) CCl₄, 2.5 h, reflux; 2.) 1 h, 20 deg C;

Reference yield:

2-pentanol (584-02-1) + acetic anhydride (108-24-7) → 2,3,5,6-tetramethylpyridine (3748-84-3) + 2,6-dimethyllutidine (20820-82-0) + 3-ethyl-2,6-dimethylpyridine (23580-52-1)

Guidance literature:

With ammonium hydroxide; Nafion-H; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) CCl₄, 2.5 h, reflux; 2.) 1 h, 20 deg C;

Reference yield:

tert-Amyl alcohol (75-85-4) + acetyl chloride (75-36-5) → 2,6-dimethyl-4-ethylpyridine (36917-36-9) + 2,6-dimethyllutidine (20820-82-0)

Guidance literature:

tert-Amyl alcohol; acetyl chloride; With trifluorormethanesulfonic acid; at 50 ℃; for 1h;

With ammonium hydroxide; Title compound not separated from byproducts;

upstream raw materials:

3,4-bis-chloromethyl-2,6-dimethyl-pyridine

2-methyl-but-2-ene

acetic anhydride

2-Methyl-1-butene

Downstream raw materials:

pyridine-2,3,4,6-tetracarboxylic acid