7-Bromo-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]-5h-pyrrolo[3,2-d]pyrimidin-2-amine

Base Information

Chemical Name:7-Bromo-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]-5h-pyrrolo[3,2-d]pyrimidin-2-amine
CAS No.:299917-00-3
Molecular Formula:C21H19 Br N4 O2
Molecular Weight:439.311
Hs Code.:
Mol file:299917-00-3.mol

Synonyms:299917-00-3;7-bromo-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]-5h-pyrrolo[3,2-d]pyrimidin-2-amine;SCHEMBL4068778;TXHHAOVCCJMUNN-UHFFFAOYSA-N;2-amino-4-benzyloxy-5-N-benzyloxymethvl-7-bromopyrrolo[3,2-d]pyrimidine;2-amino-4-benzyloxy-5-N-benzyloxymethyl-7-bromopyrrolo[3, 2-d]pyrimidine;2-amino-4-benzyloxy-5-N-benzyloxymethyl-7-bromopyrrolo[3,2-d]pyrimidine

Suppliers and Price of 7-Bromo-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]-5h-pyrrolo[3,2-d]pyrimidin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 7-Bromo-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]-5h-pyrrolo[3,2-d]pyrimidin-2-amine

Chemical Property:

PSA：75.92000
LogP:4.45940
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:438.06914
Heavy Atom Count:28
Complexity:473

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COCN2C=C(C3=C2C(=NC(=N3)N)OCC4=CC=CC=C4)Br

Technology Process of 7-Bromo-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]-5h-pyrrolo[3,2-d]pyrimidin-2-amine

There total 7 articles about 7-Bromo-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]-5h-pyrrolo[3,2-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 299916-98-6
2-amino-4-benzyloxy-5-N-benzyloxymethylpyrrolo[3,2-d]pyrimidine

: 299917-00-3
6-O-benzyl-7-N-benzyloxymethyl-9-bromo-9-deazaguanine

Guidance literature:: With N-Bromosuccinimide; In dichloromethane;
DOI:10.1021/jo0155613

Reference yield:

: 4214-85-1
2-amino-6-methyl-5-nitro-4(3H)-oxopyrimidine

: 299917-00-3
6-O-benzyl-7-N-benzyloxymethyl-9-bromo-9-deazaguanine

Guidance literature:: Multi-step reaction with 7 steps

1.1: Heating

2.1: POCl₃; N,N-diethylaniline / 0.08 h / Heating

2.2: 11.0 g / phenylmethanol / 1 h

3.1: 82 percent / dimethylformamide / 24 h / 80 °C

4.1: 85 percent / sodium dithionite / H₂O; ethanol / 0.1 h / Heating

5.1: NaH / tetrahydrofuran / 1 h

6.1: aq. NaOH / methanol / 0.5 h / Heating

7.1: 1.46 g / NBS / CH₂Cl₂

With sodium hydroxide; N-Bromosuccinimide; sodium dithionite; sodium hydride; N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo0155613

Reference yield:

: 299916-90-8
2-N-acetylamino-6-methyl-5-nitropyrimidin-4-one

: 299917-00-3
6-O-benzyl-7-N-benzyloxymethyl-9-bromo-9-deazaguanine

Guidance literature:: Multi-step reaction with 6 steps

1.1: POCl₃; N,N-diethylaniline / 0.08 h / Heating

1.2: 11.0 g / phenylmethanol / 1 h

2.1: 82 percent / dimethylformamide / 24 h / 80 °C

3.1: 85 percent / sodium dithionite / H₂O; ethanol / 0.1 h / Heating

4.1: NaH / tetrahydrofuran / 1 h

5.1: aq. NaOH / methanol / 0.5 h / Heating

6.1: 1.46 g / NBS / CH₂Cl₂

With sodium hydroxide; N-Bromosuccinimide; sodium dithionite; sodium hydride; N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo0155613