Methanimidamide, N-4-2-(dimethylamino)ethenyl-5-nitro-6-(phenylmethoxy)-2-pyrimidinyl-N,N-dimethyl-

Base Information

• Chemical Name: Methanimidamide, N-4-2-(dimethylamino)ethenyl-5-nitro-6-(phenylmethoxy)-2-pyrimidinyl-N,N-dimethyl-
• CAS No.: 299916-95-3
• Molecular Formula: C18H22 N6 O3
• Molecular Weight: 370.41
• Mol file: 299916-95-3.mol

Synonyms:Methanimidamide, N-4-2-(dimethylamino)ethenyl-5-nitro-6-(phenylmethoxy)-2-pyrimidinyl-N,N-dimethyl-

Chemical Property of Methanimidamide, N-4-2-(dimethylamino)ethenyl-5-nitro-6-(phenylmethoxy)-2-pyrimidinyl-N,N-dimethyl-

Chemical Property:

• PSA: 99.67000
• LogP: 3.24070

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanimidamide, N-4-2-(dimethylamino)ethenyl-5-nitro-6-(phenylmethoxy)-2-pyrimidinyl-N,N-dimethyl-

There total 3 articles about Methanimidamide, N-4-2-(dimethylamino)ethenyl-5-nitro-6-(phenylmethoxy)-2-pyrimidinyl-N,N-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 2-amino-4-(benzyloxy)-6-methyl-5-nitropyrimidine (160948-33-4) → 4-benzyloxy-2-[(di-N,N-methylamino)methylene]amino-6-[2-(N,N-dimethylamino)vinyl]-5-nitropyrimidine (299916-95-3)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 24h;

DOI:10.1021/jo0155613

Reference yield:

2-amino-6-methyl-5-nitro-4(3H)-oxopyrimidine (4214-85-1) → 4-benzyloxy-2-[(di-N,N-methylamino)methylene]amino-6-[2-(N,N-dimethylamino)vinyl]-5-nitropyrimidine (299916-95-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Heating

2.1: POCl₃; N,N-diethylaniline / 0.08 h / Heating

2.2: 11.0 g / phenylmethanol / 1 h

3.1: 82 percent / dimethylformamide / 24 h / 80 °C

With N,N-diethylaniline; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1021/jo0155613

Reference yield:

2-N-acetylamino-6-methyl-5-nitropyrimidin-4-one (299916-90-8) → 4-benzyloxy-2-[(di-N,N-methylamino)methylene]amino-6-[2-(N,N-dimethylamino)vinyl]-5-nitropyrimidine (299916-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: POCl₃; N,N-diethylaniline / 0.08 h / Heating

1.2: 11.0 g / phenylmethanol / 1 h

2.1: 82 percent / dimethylformamide / 24 h / 80 °C

With N,N-diethylaniline; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1021/jo0155613

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

2-amino-4-(benzyloxy)-6-methyl-5-nitropyrimidine

2-amino-6-methyl-5-nitro-4(3H)-oxopyrimidine

2-N-acetylamino-6-methyl-5-nitropyrimidin-4-one

Downstream raw materials:

6-O-benzyl-9-deaza-2-N-formylguanine

2-amino-4-benzyloxy-5-N-benzyloxymethylpyrrolo[3,2-d]pyrimidine

6-O-benzyl-7-N-benzyloxymethyl-9-bromo-9-deazaguanine

2-di-N,N-benzyl-6-O-benzyl-7-N-benzyloxymethyl-9-bromo-9-deazaguanine