[2-(4-Methoxy-phenyl)-5-thiophen-3-yl-oxazol-4-yl]-acetic acid ethyl ester

Base Information

Chemical Name:[2-(4-Methoxy-phenyl)-5-thiophen-3-yl-oxazol-4-yl]-acetic acid ethyl ester
CAS No.:99923-79-2
Molecular Formula:C₁₈H₁₇NO₄S
Molecular Weight:343.403
Hs Code.:

Synonyms:[2-(4-Methoxy-phenyl)-5-thiophen-3-yl-oxazol-4-yl]-acetic acid ethyl ester

Suppliers and Price of [2-(4-Methoxy-phenyl)-5-thiophen-3-yl-oxazol-4-yl]-acetic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [2-(4-Methoxy-phenyl)-5-thiophen-3-yl-oxazol-4-yl]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [2-(4-Methoxy-phenyl)-5-thiophen-3-yl-oxazol-4-yl]-acetic acid ethyl ester

There total 4 articles about [2-(4-Methoxy-phenyl)-5-thiophen-3-yl-oxazol-4-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 99923-64-5
3-(4-Methoxy-benzoylamino)-4-oxo-4-thiophen-3-yl-butyric acid ethyl ester

: 99923-79-2
[2-(4-Methoxy-phenyl)-5-thiophen-3-yl-oxazol-4-yl]-acetic acid ethyl ester

Guidance literature:: With trichlorophosphate; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 8h;
DOI:10.1021/jm00153a006

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 99923-79-2
[2-(4-Methoxy-phenyl)-5-thiophen-3-yl-oxazol-4-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / aq. NaHCO₃ / ethyl acetate / Ambient temperature

2: 1.) NaH / 1.) DMF, -50 - -40 deg C, 15 min, 2.) DMF, from -50 to 0 deg C, 30 min

3: 84 percent / POCl₃ / dimethylformamide / 8 h / 20 - 25 °C

With sodium hydride; sodium hydrogencarbonate; trichlorophosphate; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00153a006

Reference yield:

: 99923-47-4
4-Methoxy-N-(2-oxo-2-thiophen-3-yl-ethyl)-benzamide

: 99923-79-2
[2-(4-Methoxy-phenyl)-5-thiophen-3-yl-oxazol-4-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, -50 - -40 deg C, 15 min, 2.) DMF, from -50 to 0 deg C, 30 min

2: 84 percent / POCl₃ / dimethylformamide / 8 h / 20 - 25 °C

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00153a006