(1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-<2-(4-methoxyphenyl)-2-oxo-1-ethyl>-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

Base Information

• Chemical Name: (1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-<2-(4-methoxyphenyl)-2-oxo-1-ethyl>-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one
• CAS No.: 175222-75-0
• Molecular Formula: C₃₀H₃₅NO₇
• Molecular Weight: 521.61
• Mol file: 175222-75-0.mol

Synonyms:(1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-<2-(4-methoxyphenyl)-2-oxo-1-ethyl>-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

Chemical Property of (1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-<2-(4-methoxyphenyl)-2-oxo-1-ethyl>-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-<2-(4-methoxyphenyl)-2-oxo-1-ethyl>-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

There total 1 articles about (1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-<2-(4-methoxyphenyl)-2-oxo-1-ethyl>-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(4-methoxyphenyl)vinyloxy]trimethylsilane (55991-65-6) + (1S,4R)-1-(6,7-Dimethoxy-1,2,3,4-tetrahydro-2-isoquinolylcarbonyl)-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>-heptan-3-one (123279-28-7) → (1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-<2-(4-methoxyphenyl)-2-oxo-1-ethyl>-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one (175222-75-0) + (1S,4R)-1-<(1S)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-<2-(4-methoxyphenyl)-2-oxo-1-ethyl>-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

Guidance literature:

With trityl tetrafluoroborate; titanium tetrachloride; In dichloromethane; at -78 ℃; for 2h; Yield given. Yields of byproduct given;

DOI:10.1002/ardp.19963290104

Reference yield: 61.0%

(1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-<2-(4-methoxyphenyl)-2-oxo-1-ethyl>-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one (175222-75-0) → (1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-1-<(2S)-2-hydroxy-2-(4-methoxyphenyl)-ethyl>-6,7-dimethoxy-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one (175416-13-4) + (1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-1-<(2R)-2-hydroxy-2-(4-methoxyphenyl)-ethyl>-6,7-dimethoxy-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one (175222-77-2)

Guidance literature:

With ammonium hydroxide; hydrogen; palladium on activated charcoal; In methanol; for 26h; under 825.07 Torr; Ambient temperature;

DOI:10.1002/ardp.19963290104

Reference yield:

(1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-<2-(4-methoxyphenyl)-2-oxo-1-ethyl>-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one (175222-75-0) → (2S,11bR)-1,6,7,11b-tetrahydro-9,10-dimethoxy-2-(4-methoxyphenyl)-2H-<1,3>-oxazino<4,3-a>-isoquinoline

Guidance literature:

Multi-step reaction with 3 steps

1: 37 percent / H₂, 25percent NH₃ / 10percent Pd/C / methanol / 26 h / 825.07 Torr / Ambient temperature

2: 87 percent / 0.5 N KOH / methanol; H₂O / 144 h / Ambient temperature

3: diethyl ether / 17 h / Ambient temperature

With potassium hydroxide; ammonium hydroxide; hydrogen; palladium on activated charcoal; In methanol; diethyl ether; water;

DOI:10.1002/ardp.19963290104

upstream raw materials:

[1-(4-methoxyphenyl)vinyloxy]trimethylsilane

(1S,4R)-1-(6,7-Dimethoxy-1,2,3,4-tetrahydro-2-isoquinolylcarbonyl)-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>-heptan-3-one

Downstream raw materials:

(1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-1-<(2S)-2-hydroxy-2-(4-methoxyphenyl)-ethyl>-6,7-dimethoxy-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

(1S,4R)-1-<(1R)-1,2,3,4-tetrahydro-1-<(2R)-2-hydroxy-2-(4-methoxyphenyl)-ethyl>-6,7-dimethoxy-2-isoquinolylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-one

(1S)-1-(4-methoxyphenyl)-2-<(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolyl>ethanol

(1R)-1-(4-methoxyphenyl)-2-<(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolyl>ethanol