(S)-4-benzyl-3-((S)-4,4,4-trifluoro-3-(4-fluorophenylamino)butanoyl)oxazolidin-2-one

Base Information

Chemical Name:(S)-4-benzyl-3-((S)-4,4,4-trifluoro-3-(4-fluorophenylamino)butanoyl)oxazolidin-2-one
CAS No.:1451061-28-1
Molecular Formula:C₂₀H₁₈F₄N₂O₃
Molecular Weight:410.368
Hs Code.:

Synonyms:(S)-4-benzyl-3-((S)-4,4,4-trifluoro-3-(4-fluorophenylamino)butanoyl)oxazolidin-2-one

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Chemical Property of (S)-4-benzyl-3-((S)-4,4,4-trifluoro-3-(4-fluorophenylamino)butanoyl)oxazolidin-2-one

Chemical Property:

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Technology Process of (S)-4-benzyl-3-((S)-4,4,4-trifluoro-3-(4-fluorophenylamino)butanoyl)oxazolidin-2-one

There total 1 articles about (S)-4-benzyl-3-((S)-4,4,4-trifluoro-3-(4-fluorophenylamino)butanoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1451061-27-0
(S,Z)-4-benzyl-3-(4,4,4-trifluoro-3-(4-fluorophenylamino)but-2-enoyl)oxazolidin-2-one

: 1451061-28-1
(S)-4-benzyl-3-((S)-4,4,4-trifluoro-3-(4-fluorophenylamino)butanoyl)oxazolidin-2-one

: (S)-4-benzyl-3-((R)-4,4,4-trifluoro-3-(4-fluorophenylamino)butanoyl)oxazolidin-2-one

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 24h; Overall yield = 70 %;
DOI:10.1016/j.tetlet.2013.08.027

Reference yield:

: 1451061-28-1
(S)-4-benzyl-3-((S)-4,4,4-trifluoro-3-(4-fluorophenylamino)butanoyl)oxazolidin-2-one

: 1451061-29-2
C₁₀H₉F₄NO₂

Guidance literature:: With lithium hydroxide monohydrate; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 1h;
DOI:10.1016/j.tetlet.2013.08.027

Reference yield:

: 1451061-28-1
(S)-4-benzyl-3-((S)-4,4,4-trifluoro-3-(4-fluorophenylamino)butanoyl)oxazolidin-2-one

: 1451061-24-7
(3R,4S)-1-(4-fluorophenyl)-3-(3-phenylpropyl)-4-(trifluoromethyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: dihydrogen peroxide; lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 0 °C

2.1: thionyl chloride / 1.5 h / 5 - 60 °C

3.1: methylmagnesium bromide / diethyl ether / 0.75 h / -12 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

4.2: 0.5 h / -78 °C / Inert atmosphere

4.3: 4 h / -78 °C / Inert atmosphere

With thionyl chloride; lithium hydroxide monohydrate; methylmagnesium bromide; dihydrogen peroxide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; hexane; water;
DOI:10.1016/j.tetlet.2013.08.027