1451061-29-2Relevant academic research and scientific papers
An aza-Michael addition protocol to fluoroalkylated β-amino acid derivatives and enantiopure trifluoromethylated N-heterocycles
Yang, Xing,Chen, Zhuo,Cai, Yuan,Huang, Yi-Yong,Shibata, Norio
, p. 4530 - 4534 (2014/12/10)
The aza-Michael reaction with β-fluoroalkylated acrylates provided the corresponding fluoroalkylated β-amino acid derivatives in up to 99% yield under catalyst- and solvent-free conditions. An enantioenriched β-trifluoromethylated β-amino acid was obtained in good yield through a scale-up diastereoselective aza-Michael addition, which facilitated the installation of enantiopure trifluoromethylated analogues of β-lactam and dihydroquinolin-4-one. This journal is
4-CF3-ezetimibe analogs: Design, synthesis, and biological evaluation of cholesterol absorption inhibitions
Liu, Yingle,Chen, Jun-Ling,Wang, Gai-Hong,Sun, Peng,Huang, Heyao,Qing, Feng-Ling
, p. 5541 - 5543 (2013/09/23)
On the purpose of looking for better cholesterol absorption inhibitors, several trifluoromethyl substituted ezetimibe analogs 1a-d were designed and synthesized. The key steps in the synthesis of these optically pure trans-4-CF3-β-lactams inclu
