10130-87-7

Basic information

• Product Name: 2-METHOXYBENZENESULFONYL CHLORIDE
• Synonyms: AKOS BB-9465;2-METHOXYBENZENESULFONYL CHLORIDE;5-Methoxybenzenesulfonyl chloride;2-Methoxybenzene-1-sulfonyl chloride;2-(Methyloxy)benzenesulfonyl chloride;2-Methoxyphenylsulfonyl chloride;o-Methoxybenzenesulfonyl chloride
• CAS NO: 10130-87-7
• Molecular Formula: C₇H₇ClO₃S
• Molecular Weight: 206.65
• Mol File: 10130-87-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 50-54°C
• Boiling Point: 305.1 °C at 760 mmHg
• Flash Point: 138.3 °C
• Appearance: /
• Density: 1.376
• Vapor Pressure: 0.00152mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2-METHOXYBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXYBENZENESULFONYL CHLORIDE(10130-87-7)
• EPA Substance Registry System: 2-METHOXYBENZENESULFONYL CHLORIDE(10130-87-7)

Safety Data

• Hazard Codes: Xi
• Statements: 34-43
• Safety Statements: 26-36/37/39-36/37
• RIDADR: 3261
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 10130-87-7(Hazardous Substances Data)

Usage

Uses

For synthesis and pharmacological evaluation of sulfonamide derivatives of thiazolidin-4-ones 5-Bromo-2-methoxybenzenesulfonyl chloride is used.

InChI:InChI=1/C7H7ClO3S/c1-11-6-4-2-3-5-7(6)12(8,9)10/h2-5H,1H3

Upstream product

• 7217-59-6 2-Methoxybenzenethiol 
• 100-66-3 methoxybenzene 
• 578-57-4 2-bromoanisole 
• 68516-52-9 2-methoxyphenylmagnesium chloride 
• 3425-23-8 2-methoxybenzenediazonium chloride 
• 13165-78-1 ortho-methoxybenzenesulfinic acid 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 681439-92-9 2-methoxy-N-phenethyl-benzenesulfonamide 
• 16641-71-7 1-(phenoxycarbonyl)piperidine 
• 69630-20-2 4-(phenyloxycarbonyl)morpholine 
• 55379-71-0 phenyl pyrrolidine-1-carboxylate 
• 681440-00-6 2-methoxy-N-methyl-N-(1-phenyl-ethyl)-benzenesulfonamide 
• 681439-94-1 (S)-2-Benzyl-1-(2-methoxy-benzenesulfonyl)-aziridine 
• 681440-04-0 N-(1-hydroxymethyl-2-phenyl-ethyl)-2-methoxy-benzenesulfonamide 
• 681440-05-1 N-(1-hydroxymethyl-2-phenyl-ethyl)-2-methoxy-N-methyl-benzenesulfonamide 
• 681440-03-9 N-benzyl-2-methoxy-N-phenyl-benzenesulfonamide 
• 681440-01-7 N-benzyl-2-methoxy-N-(1-methyl-1-phenyl-ethyl)-benzenesulfonamide 
• 681440-06-2 N-(1-benzyloxymethyl-2-phenyl-ethyl)-2-methoxy-N-methyl-benzenesulfonamide 
• 681440-02-8 N-decyl-2-methoxy-N-phenethyl-benzenesulfonamide 
• 874569-06-9 tert-butyl 3-({[(2-methoxyphenyl)sulfonyl]amino}methyl)piperidinecarboxylate 
• 1333114-59-2 4-(4-bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahvdro-1H-benzo-[f][1,4]oxazocine 

Relevant articles and documents

Sulfonyl halide synthesis by thiol oxyhalogenation using NBS/NCS – iPrOH

A rapid and facile method provides a general route to sulfonyl bromides/chlorides by the oxidation of thiols using NXS – ROH (X?=?Br,Cl, R?=?iPr) as an oxyhalogenation reagent. Control experiments suggest that the alcohol component is the source of oxygen. The proposed method enable the access to structurally diverse sulfonyl bromides and chlorides including challenging examples, inaccessible by other synthetic methods.

Conversion of thiols into sulfonyl halogenides under aerobic and metal-free conditions

An environmentally benign, metal-free synthesis of sulfonyl chlorides and bromides from thiols in the presence of ammonium nitrate, an aqueous solution of HCl and HBr and oxygen as a terminal oxidant was developed. The reactivity of various substituted thiophenols, benzylic-, aliphatic- and heteroaromatic thiols was examined. Ammonium nitrate served as a source of nitrogen oxides (NO/NO2), which are the crucial players in a redox-catalytic cycle. Sulfonyl chlorides and bromides were isolated without extraction and "filtered" over a short pad of silica gel; the use of solvents was greatly reduced in comparison with traditional isolation and purification. A "one-pot" protocol for the conversion of thiol into sulfonamide is also demonstrated. Scale-up experiments on the preparation of sulfonyl chloride and bromide are shown. A possible reaction pathway is discussed.

Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists

The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.