(S)-2-[(R)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-hex-4-enoic acid methoxy-methyl-amide

Base Information

Chemical Name:(S)-2-[(R)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-hex-4-enoic acid methoxy-methyl-amide
CAS No.:733000-64-1
Molecular Formula:C₂₄H₄₁NO₄Si
Molecular Weight:435.679
Hs Code.:

Synonyms:(S)-2-[(R)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-hex-4-enoic acid methoxy-methyl-amide

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Chemical Property of (S)-2-[(R)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-hex-4-enoic acid methoxy-methyl-amide

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Technology Process of (S)-2-[(R)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-hex-4-enoic acid methoxy-methyl-amide

There total 3 articles about (S)-2-[(R)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-hex-4-enoic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 733000-61-8
(S)-2-((R)-2-Benzyloxy-1-hydroxy-ethyl)-5-methyl-hex-4-enoic acid methoxy-methyl-amide

: 733000-64-1
(S)-2-[(R)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-hex-4-enoic acid methoxy-methyl-amide

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1002/ejoc.200400047

Reference yield:

: 870-63-3
prenyl bromide

: 733000-64-1
(S)-2-[(R)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-hex-4-enoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / HMPA; LDA / tetrahydrofuran / 5 h / -78 - 0 °C

2: 92 percent / nBuLi / tetrahydrofuran; hexane / 2 h / -78 °C

3: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/ejoc.200400047

Reference yield:

: 733000-60-7
(S)-2-((R)-2-Benzyloxy-1-hydroxy-ethyl)-5-methyl-hex-4-enoic acid ethyl ester

: 733000-64-1
(S)-2-[(R)-2-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-hex-4-enoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / nBuLi / tetrahydrofuran; hexane / 2 h / -78 °C

2: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

With 2,6-dimethylpyridine; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/ejoc.200400047