3'-(4-fluorophenyl)-5-methylspiro[3H-indole-3,2'-thiazolidine]-2,4'-(1H)-dione

Base Information

Chemical Name:3'-(4-fluorophenyl)-5-methylspiro[3H-indole-3,2'-thiazolidine]-2,4'-(1H)-dione
CAS No.:1373763-27-9
Molecular Formula:C₁₇H₁₃FN₂O₂S
Molecular Weight:328.367
Hs Code.:

Synonyms:3'-(4-fluorophenyl)-5-methylspiro[3H-indole-3,2'-thiazolidine]-2,4'-(1H)-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-(4-fluorophenyl)-5-methylspiro[3H-indole-3,2'-thiazolidine]-2,4'-(1H)-dione

Chemical Property:

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Technology Process of 3'-(4-fluorophenyl)-5-methylspiro[3H-indole-3,2'-thiazolidine]-2,4'-(1H)-dione

There total 3 articles about 3'-(4-fluorophenyl)-5-methylspiro[3H-indole-3,2'-thiazolidine]-2,4'-(1H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 608-05-9
5-methyl-indole-2,3-dione

: 68-11-1
mercaptoacetic acid

: 371-40-4
4-fluoroaniline

: 1373763-27-9
3'-(4-fluorophenyl)-5-methylspiro[3H-indole-3,2'-thiazolidine]-2,4'-(1H)-dione

Guidance literature:: With 1-methylimidazolium tetrafluoroborate; at 140 ℃; for 0.0666667h; Microwave irradiation; Ionic liquid;
DOI:10.1016/j.jfluchem.2012.03.003

Reference yield: 88.0%

: 66440-29-7
C₁₅H₁₁FN₂O

: 68-11-1
mercaptoacetic acid

: 1373763-27-9
3'-(4-fluorophenyl)-5-methylspiro[3H-indole-3,2'-thiazolidine]-2,4'-(1H)-dione

Guidance literature:: In water; for 4h; Reflux;
DOI:10.1007/s00706-011-0697-x

Reference yield:

: 608-05-9
5-methyl-indole-2,3-dione

: 371-40-4
4-fluoroaniline

: 1373763-27-9
3'-(4-fluorophenyl)-5-methylspiro[3H-indole-3,2'-thiazolidine]-2,4'-(1H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: water / 4.5 h / 20 °C

2: water / 4 h / Reflux

In water;
DOI:10.1007/s00706-011-0697-x