(5R)-5-(1,1-dimethylethyl)-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione

Base Information

Chemical Name:(5R)-5-(1,1-dimethylethyl)-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione
CAS No.:1311136-98-7
Molecular Formula:C₂₀H₂₃N₃O₄
Molecular Weight:369.42
Hs Code.:

Synonyms:(5R)-5-(1,1-dimethylethyl)-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione

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Chemical Property of (5R)-5-(1,1-dimethylethyl)-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione

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Technology Process of (5R)-5-(1,1-dimethylethyl)-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione

There total 9 articles about (5R)-5-(1,1-dimethylethyl)-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 26782-71-8
D-tert-leucine

: 1311136-98-7
(5R)-5-(1,1-dimethylethyl)-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; methanol / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 20 - 50 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

4.1: triethylamine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

With triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1311138-51-8
3-methyl-N'-(6-{[4-methyll-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-valinamide

: 1311136-98-7
(5R)-5-(1,1-dimethylethyl)-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h; Inert atmosphere;

Reference yield:

: 19217-50-6
4-methyl-3-(methyloxy)phenol

: 1311136-98-7
(5R)-5-(1,1-dimethylethyl)-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 115 °C

2.1: water; ammonium chloride / iron / tetrahydrofuran / 8 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 20 - 50 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

5.1: triethylamine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

With water; potassium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; iron; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;