3-methyl-N'-(6-{[4-methyll-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-valinamide

Base Information

Chemical Name:3-methyl-N'-(6-{[4-methyll-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-valinamide
CAS No.:1311138-51-8
Molecular Formula:C₁₉H₂₅N₃O₃
Molecular Weight:343.426
Hs Code.:

Synonyms:3-methyl-N'-(6-{[4-methyll-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-valinamide

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Chemical Property of 3-methyl-N'-(6-{[4-methyll-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-valinamide

Chemical Property:

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Technology Process of 3-methyl-N'-(6-{[4-methyll-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-valinamide

There total 8 articles about 3-methyl-N'-(6-{[4-methyll-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-valinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 26782-71-8
D-tert-leucine

: 1311138-51-8
3-methyl-N'-(6-{[4-methyll-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-valinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; methanol / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 20 - 50 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1311138-50-7
1,1-dimethylethyl ((1R)-2,2-dimethyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate

: 1311138-51-8
3-methyl-N'-(6-{[4-methyll-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-valinamide

Guidance literature:: 1,1-dimethylethyl ((1R)-2,2-dimethyl-1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}propyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 3h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 19217-50-6
4-methyl-3-(methyloxy)phenol

: 1311138-51-8
3-methyl-N'-(6-{[4-methyll-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-valinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 115 °C

2.1: water; ammonium chloride / iron / tetrahydrofuran / 8 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 20 - 50 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

With water; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; iron; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;