2-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)benzamide

Base Information

Chemical Name:2-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)benzamide
CAS No.:1610889-53-6
Molecular Formula:C₂₁H₂₄F₃NOS
Molecular Weight:395.489
Hs Code.:

Synonyms:2-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)benzamide

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Chemical Property of 2-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)benzamide

Chemical Property:

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Technology Process of 2-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)benzamide

There total 7 articles about 2-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 107-85-7
1-amino-3-methylbutane

: 1610889-85-4
2-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]benzoic acid

: 1610889-53-6
2-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)benzamide

Guidance literature:: 2-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]benzoic acid; With triethylamine; HATU; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

1-amino-3-methylbutane; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1242643-02-2
acetic acid 2-[2-(4-fluorophenyl)-[1,3]dithiolan-2-yl]ethyl ester

: 1610889-53-6
2-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridine hydrofluoride / dichloromethane / 3.5 h / -78 - 20 °C

2.1: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

4.1: potassium carbonate / acetone / 2.5 h / 70 °C

5.1: HATU; triethylamine / tetrahydrofuran / 0.08 h / 20 °C

5.2: 2 h / 20 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; carbon tetrabromide; pyridine hydrofluoride; water; potassium carbonate; triethylamine; triphenylphosphine; HATU; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetone;

Reference yield:

: 66267-03-6
acetic acid [3-(4-fluorophenyl)-3-oxopropyl] ester

: 1610889-53-6
2-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]-N-(3-methylbutyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 6 h / 0 - 20 °C

2.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridine hydrofluoride / dichloromethane / 3.5 h / -78 - 20 °C

3.1: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

5.1: potassium carbonate / acetone / 2.5 h / 70 °C

6.1: HATU; triethylamine / tetrahydrofuran / 0.08 h / 20 °C

6.2: 2 h / 20 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; carbon tetrabromide; pyridine hydrofluoride; boron trifluoride diethyl etherate; water; potassium carbonate; triethylamine; triphenylphosphine; HATU; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetone;