4-[4-(3-{2-[(3 R)-3-(methoxymethyl)pyrrolidinyl]-2-oxoethoxy}phenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxamidine trifluoroacetate

Base Information

• Chemical Name: 4-[4-(3-{2-[(3 R)-3-(methoxymethyl)pyrrolidinyl]-2-oxoethoxy}phenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxamidine trifluoroacetate
• CAS No.: 288396-72-5
• Molecular Formula: C₂HF₃O₂*C₂₃H₂₆N₄O₃S₃
• Molecular Weight: 616.706

Synonyms:4-[4-(3-{2-[(3 R)-3-(methoxymethyl)pyrrolidinyl]-2-oxoethoxy}phenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxamidine trifluoroacetate

Chemical Property of 4-[4-(3-{2-[(3 R)-3-(methoxymethyl)pyrrolidinyl]-2-oxoethoxy}phenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxamidine trifluoroacetate

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Technology Process of 4-[4-(3-{2-[(3 R)-3-(methoxymethyl)pyrrolidinyl]-2-oxoethoxy}phenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxamidine trifluoroacetate

There total 2 articles about 4-[4-(3-{2-[(3 R)-3-(methoxymethyl)pyrrolidinyl]-2-oxoethoxy}phenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxamidine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

2-{3-[2-(5-amidino-2-methylthio-thien-3-yl)-1,3-thiazol-4-yl]phenoxy}acetic acid (237381-57-6) + O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate) HATU + (2S)-2-(methoxymethyl)-1-pyrrolidine (63126-47-6) → 4-[4-(3-{2-[(3 R)-3-(methoxymethyl)pyrrolidinyl]-2-oxoethoxy}phenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxamidine trifluoroacetate (288396-72-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield: 35.0%

2-{3-[2-(5-amidino-2-methylthio-thien-3-yl)-1,3-thiazol-4-yl]phenoxy}acetic acid (237381-57-6) + (2S)-2-(methoxymethyl)-1-pyrrolidine (63126-47-6) → 4-[4-(3-{2-[(3 R)-3-(methoxymethyl)pyrrolidinyl]-2-oxoethoxy}phenyl)(1,3-thiazol-2-yl)]-5-methylthiothiophene-2-carboxamidine trifluoroacetate (288396-72-5)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

upstream raw materials:

2-{3-[2-(5-amidino-2-methylthio-thien-3-yl)-1,3-thiazol-4-yl]phenoxy}acetic acid

(2S)-2-(methoxymethyl)-1-pyrrolidine

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