(1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane

Base Information

Chemical Name:(1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane
CAS No.:208989-26-8
Molecular Formula:C₂₄H₃₀FNOS
Molecular Weight:399.573
Hs Code.:

(1S,5S,7R,R<sub>S</sub>)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane

Synonyms:(1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane

Suppliers and Price of (1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane

Chemical Property:

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Technology Process of (1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane

There total 8 articles about (1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Thiocarbonic acid O-[(1S,3R,4S,5S,6R)-3-(4-fluoro-phenyl)-8-methyl-4-propyl-6-((R)-toluene-4-sulfinyl)-8-aza-bicyclo[3.2.1]oct-2-yl] ester O-phenyl ester

: 208989-26-8
(1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 90 ℃; for 1h; Yield given;
DOI:10.1021/jm9802564

Reference yield:

: 54828-68-1
(R)-p-tolyl vinyl sulfoxide

: 208989-26-8
(1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 45 percent / dioxane / 24 h / Heating

2.1: CuBr*Me₂S; TMSCl; HMPA / tetrahydrofuran / -78 °C

3.1: LiBH₄ / tetrahydrofuran / 20 °C

4.1: n-BuLi / tetrahydrofuran

4.2: tetrahydrofuran / -78 °C

5.1: n-Bu₃SnH; AIBN / toluene / 60 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium borohydride; n-butyllithium; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; 1,4-dioxane; toluene; 1.1: Cycloaddition / 2.1: Addition / 3.1: Reduction / 4.1: Metallation / 4.2: Thioacylation / 5.1: Deoxygenation;
DOI:10.1016/S0960-894X(00)00269-9

Reference yield:

: 208989-15-5
(1S,5S,6R,R_S)-3-(p-fluorophenyl)-N-methyl-6-(p-tolylsulfinyl)-8-azabicyclo<3.2.1>oct-3-en-2-one

: 208989-26-8
(1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane

Guidance literature:: Multi-step reaction with 4 steps

1.1: CuBr*Me₂S; TMSCl; HMPA / tetrahydrofuran / -78 °C

2.1: LiBH₄ / tetrahydrofuran / 20 °C

3.1: n-BuLi / tetrahydrofuran

3.2: tetrahydrofuran / -78 °C

4.1: n-Bu₃SnH; AIBN / toluene / 60 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium borohydride; n-butyllithium; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; toluene; 1.1: Addition / 2.1: Reduction / 3.1: Metallation / 3.2: Thioacylation / 4.1: Deoxygenation;
DOI:10.1016/S0960-894X(00)00269-9