208989-15-5

Upstream product

• 54828-68-1 (R)-p-tolyl vinyl sulfoxide 
• 208989-10-0 4-(p-fluorophenyl)-1-methyl-3-pyridiniumolate 
• 27328-17-2 (S)-(-)-p-tolyl vinyl sulfoxide 

Downstream Products

• 208989-25-7 (1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-phenyl-7β-(p-tolylsulfinyl)tropane 
• 290810-02-5 (1S,2S,3R,5R,7R)-7-Fluoro-3-(4-fluoro-phenyl)-8-methyl-2-propyl-7-(toluene-4-sulfonyl)-8-aza-bicyclo[3.2.1]octane 
• 290809-98-2 (1S,2S,3R,4S,5S,6R)-3-(4-Fluoro-phenyl)-8-methyl-4-propyl-6-((R)-toluene-4-sulfinyl)-8-aza-bicyclo[3.2.1]octan-2-ol 
• 290809-99-3 (1S,2S,3R,5R,7R)-3-(4-Fluoro-phenyl)-8-methyl-2-propyl-7-(toluene-4-sulfonyl)-8-aza-bicyclo[3.2.1]octane 
• 290810-01-4 (1R,3R,4S,5S,6S)-3-(4-Fluoro-phenyl)-8-methyl-4-propyl-8-aza-bicyclo[3.2.1]octan-6-ol 
• 290810-00-3 (1R,3R,4S,5S)-3-(4-Fluoro-phenyl)-8-methyl-4-propyl-8-aza-bicyclo[3.2.1]octan-6-one 
• 208989-26-8 (1S,5S,7R,R_S)-3α-(p-fluorophenyl)-2β-n-propyl-7β-(p-tolylsulfinyl)tropane 
• 208989-19-9 (1S,5S,6R,R_S)-3α-(p-fluorophenyl)-N-methyl-4β-phenyl-6β-(p-tolylsulfinyl)-8-azabicyclo<3.2.1>octan-2-one 
• 208989-21-3 (1S,5S,6R,R_S)-3α-(p-fluorophenyl)-N-methyl-4β-n-propyl-6β-(p-tolylsulfinyl)-8-azabicyclo<3.2.1>octan-2-one 

Relevant academic research and scientific papers

An enantioselective synthesis and biobehavioral evaluation of 7-fluoro-3-(p-fluorophenyl)-2-propyltropanes

Optically pure 7-fluorotropanes 3a-c, were synthesized as structural probes of the dopamine transporter. The synthesis of these compounds was accomplished through the asymmetric 1,3-dipolar cycloaddition reaction of the oxidopyridinium betaine 4 with the chiral dipolarophile (R)-p-tolyl vinyl sulfoxide. In the preliminary analysis, tropane 3a was found to reduce the rewarding effects of cocaine in the brain stimulation reward paradigm. (C) 2000 Elsevier Science Ltd. All rights reserved.

Tropane derivatives and method for their synthesis

A compound of formula (I) wherein R1-R6have any of the values defined in the specification are described, as well as pharmaceutical compositions comprising a compound of formula (I), and methods for preparing and using compounds of f

Synthesis and biological properties of new 2β-alkyl- and 2β-aryl-3- (substituted phenyl)tropane derivatives: Stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters

In our efforts to identify molecules that might act as cocaine antagonists or cocaine partial agonists, we have been involved in efforts to further elucidate the nature of cocaine's binding to the dopamine transporter (DAT) through strategic modifications