(S,E)-1-methyl-4-((1-phenylpent-1-en-3-yl)sulfonyl)benzene

Base Information

• Chemical Name: (S,E)-1-methyl-4-((1-phenylpent-1-en-3-yl)sulfonyl)benzene
• CAS No.: 1397699-75-0
• Molecular Formula: C₁₈H₂₀O₂S
• Molecular Weight: 300.422
• Mol file: 1397699-75-0.mol

Synonyms:(S,E)-1-methyl-4-((1-phenylpent-1-en-3-yl)sulfonyl)benzene

Chemical Property of (S,E)-1-methyl-4-((1-phenylpent-1-en-3-yl)sulfonyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,E)-1-methyl-4-((1-phenylpent-1-en-3-yl)sulfonyl)benzene

There total 3 articles about (S,E)-1-methyl-4-((1-phenylpent-1-en-3-yl)sulfonyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C11H15N + sodium 4-methylbenzenesulfinate (824-79-3) → (S,E)-1-methyl-4-((1-phenylpent-1-en-3-yl)sulfonyl)benzene (1397699-75-0)

Guidance literature:

sodium 4-methylbenzenesulfinate; With bis(η3-allyl-μ-chloropalladium(II)); 1,1'-bisnaphthalene; boric acid; In 1,4-dioxane; at 20 ℃; for 0.0833333h; Inert atmosphere;

C₁₁H₁₅N; In 1,4-dioxane; at 20 - 100 ℃; for 4.5h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ja306407x

Reference yield: 93.0%

p-toluene sulfinic acid (536-57-2) + ((1E)-penta-1,3-dien-1-yl)benzene (1608-27-1,3909-96-4,7642-05-9,39491-55-9,39491-56-0,66597-13-5,66597-12-4) → (S,E)-1-methyl-4-((1-phenylpent-1-en-3-yl)sulfonyl)benzene (1397699-75-0)

Guidance literature:

With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tert-butyl methyl ether; at 30 ℃; for 30h; enantioselective reaction; Glovebox;

DOI:10.1021/jacs.0c05976

Reference yield:

(1E,3E)-1-phenyl-1,3-pentadiene (3909-96-4) + toluene-4-sulfonic acid hydrazide (1576-35-8) → (S,E)-1-methyl-4-((1-phenylpent-1-en-3-yl)sulfonyl)benzene (1397699-75-0) + (E)-1-methyl-4-((1-phenylpent-1-en-3-yl)sulfonyl)benzene

Guidance literature:

With palladium diacetate; (R)-9-(4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-yl)-9H-carbazole; toluene-4-sulfonic acid; In diethylene glycol dimethyl ether; at 80 ℃; for 24h; Overall yield = 37 percent; enantioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.202012485

upstream raw materials:

sodium 4-methylbenzenesulfinate

p-toluene sulfinic acid

((1E)-penta-1,3-dien-1-yl)benzene

(1E,3E)-1-phenyl-1,3-pentadiene