2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Base Information

• Chemical Name: 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
• CAS No.: 93849-02-6
• Molecular Formula: C₂₄H₃₂ClN₃O₈S
• Molecular Weight: 558.052
• Mol file: 93849-02-6.mol

Synonyms:2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Chemical Property of 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

There total 8 articles about 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

morpholine-4-sulfonyl chloride (1828-66-6) + 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (88150-42-9) → 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (93849-02-6)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00159a022

Reference yield:

ethyl (2-chloroaceto)acetate (638-07-3) → 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (93849-02-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, 1 h, 2.) THF, RT, overnight

2: 25 percent / propan-2-ol / 21 h / Heating

3: methylamine / ethanol / 3 h / Ambient temperature

4: 75 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With sodium hydride; triethylamine; methylamine; In ethanol; dichloromethane; isopropyl alcohol;

DOI:10.1021/jm00159a022

Reference yield:

2-(2-azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (88150-46-3) → 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (93849-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/CaCO₃ / ethanol / 1 h / Ambient temperature

2: 75 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With hydrogen; triethylamine; Lindlar's catalyst; In ethanol; dichloromethane;

DOI:10.1021/jm00159a022

upstream raw materials:

morpholine-4-sulfonyl chloride

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

ethyl (2-chloroaceto)acetate

2-(2-azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine