88150-46-3

Basic information

• Product Name: 2-[(2-AZIDOETHOXY)METHYL]-4-(2-CHLOROPHENYL)-3-ETHOXYCARBONYL-5-METHOXYCARBONYL)-6-METHYL-1,4-DIHYDROPYRIDINE
• Synonyms: 2-[(2-AZIDOETHOXY)METHYL]-4-(2-CHLOROPHENYL)-3-ETHOXYCARBONYL-5-METHOXYCARBONYL)-6-METHYL-1,4-DIHYDROPYRIDINE;2-[(2-Azidoethoxy)Methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-Methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester;AMlodipine Azido Analog
• CAS NO: 88150-46-3
• Molecular Formula: C₂₀H₂₃ClN₄O₅
• Molecular Weight: 434.87342
• Product Categories: Dihydropyridine Class Chemicals;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Dihydropyridine
• Mol File: 88150-46-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 143-145°C
• Appearance: /
• Storage Temp.: Refrigerator
• CAS DataBase Reference: 2-[(2-AZIDOETHOXY)METHYL]-4-(2-CHLOROPHENYL)-3-ETHOXYCARBONYL-5-METHOXYCARBONYL)-6-METHYL-1,4-DIHYDROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-AZIDOETHOXY)METHYL]-4-(2-CHLOROPHENYL)-3-ETHOXYCARBONYL-5-METHOXYCARBONYL)-6-METHYL-1,4-DIHYDROPYRIDINE(88150-46-3)
• EPA Substance Registry System: 2-[(2-AZIDOETHOXY)METHYL]-4-(2-CHLOROPHENYL)-3-ETHOXYCARBONYL-5-METHOXYCARBONYL)-6-METHYL-1,4-DIHYDROPYRIDINE(88150-46-3)

Safety Data

• Hazardous Substances Data: 88150-46-3(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

Different sources of media describe the Uses of 88150-46-3 differently. You can refer to the following data:
1. A dihydropyridine.
2. An impurity arising in the synthesis of amlodipine (A633500).

InChI:InChI=1/C20H23ClN4O5/c1-4-30-20(27)18-15(11-29-10-9-23-25-22)24-12(2)16(19(26)28-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,24H,4,9-11H2,1-3H3

Upstream product

• 68064-69-7 (Z)-methyl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate 
• 67593-46-8 methyl (Z)-2-acetyl-3-(2-chlorophenyl)acrylate 
• 88150-42-9 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 67593-46-8 methyl 2-(2-chlorophenylmethylene)acetoacetate 
• 1517-05-1 2-azidoethanol 
• 88150-45-2 ethyl 4-(2-azidoethoxy)acetoacetate 
• 1257662-59-1 2-azidoethyl ethyl malonate 
• 89-98-5 2-chloro-benzaldehyde 
• 14205-39-1 methyl (E)-3-aminocrotonate 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 67-56-1 methanol 
• 120289-15-8 2-(2-azidoethoxy)methyl-5-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine 

Downstream Products

• 88150-42-9 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 88150-47-4 (RS)-amlodipine maleate 
• 97801-20-2 2-[2-(4-Carbamoyl-[1,2,3]triazol-1-yl)-ethoxymethyl]-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 97801-21-3 2-[2-(5-Carbamoyl-[1,2,3]triazol-1-yl)-ethoxymethyl]-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 93849-02-6 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 97801-17-7 4-(2-Chloro-phenyl)-2-[2-(5-ethoxycarbonyl-[1,2,3]triazol-1-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 97801-16-6 4-(2-Chloro-phenyl)-2-[2-(4-ethoxycarbonyl-[1,2,3]triazol-1-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 90444-73-8 3-ethyl 5-methyl 2-((2-(1H-1,2,3-triazol-1-yl)ethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant articles and documents

Modular click chemistry libraries for functional screens using a diazotizing reagent

Click chemistry is a concept in which modular synthesis is used to rapidly find new molecules with desirable properties1. Copper(i)-catalysed azide–alkyne cycloaddition (CuAAC) triazole annulation and sulfur(vi) fluoride exchange (SuFEx) catalysis are widely regarded as click reactions2–4, providing rapid access to their products in yields approaching 100% while being largely orthogonal to other reactions. However, in the case of CuAAC reactions, the availability of azide reagents is limited owing to their potential toxicity and the risk of explosion involved in their preparation. Here we report another reaction to add to the click reaction family: the formation of azides from primary amines, one of the most abundant functional groups5. The reaction uses just one equivalent of a simple diazotizing species, fluorosulfuryl azide6–11 (FSO2N3), and enables the preparation of over 1,200 azides on 96-well plates in a safe and practical manner. This reliable transformation is a powerful tool for the CuAAC triazole annulation, the most widely used click reaction at present. This method greatly expands the number of accessible azides and 1,2,3-triazoles and, given the ubiquity of the CuAAC reaction, it should find application in organic synthesis, medicinal chemistry, chemical biology and materials science.

Long-acting dihydropyridine calcium antagonists. 1. 2-alkoxymethyl derivatives incorporating basic substituents

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2-(SECONDARY AMINOALKOXYMETHYL) DIHYDROPYRIDINE DERIVATIVES AS ANTI-ISCHAEMIC AND ANTIHYPERTENSIVE AGENTS

A dihydropyridine compound of the formula or a pharmaceutically acceptable acid addition salt thereof, wherein Y is -(CH2)2-, -(CH2)3-, -CH2CH(CH3)-or -CH2C(CH3)2-; R is aryl or heteroaryl; R1 and R2 are each independently C1-C4 alkyl or 2-methoxyethyl; and R3 is hydrogen, C1-C4 alkyl, 2-(Ci-C4 alkoxy)ethyl, cyclopropylmethyl, benzyl, or -(CH2)mCOR4 where m is 1, 2 or 3 and R4 is hydroxy, C1-C4 alkoxy or -NR5R6 where R5 and R6 are each independently hydrogen or C1-C4 alkyl can be employed for treating or preventing a heart condition or hypertension.