2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-3,4-dihydro-2H-quinolin-1-yl)-ethanone

Base Information

Chemical Name:2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-3,4-dihydro-2H-quinolin-1-yl)-ethanone
CAS No.:135709-59-0
Molecular Formula:C₂₂H₂₄Cl₂N₂O
Molecular Weight:403.351
Hs Code.:

Synonyms:2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-3,4-dihydro-2H-quinolin-1-yl)-ethanone

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Chemical Property of 2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-3,4-dihydro-2H-quinolin-1-yl)-ethanone

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Technology Process of 2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-3,4-dihydro-2H-quinolin-1-yl)-ethanone

There total 6 articles about 2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-3,4-dihydro-2H-quinolin-1-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93-10-7,1199266-78-8
quinoline-2-carboxylic acid

: 135709-59-0
2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-3,4-dihydro-2H-quinolin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / Heating

2: 92 percent / H₂, 20percent methanolic HCl / PtO₂ / 8 h / 775.7 Torr

3: 71 percent / H₂O / 15 h / Ambient temperature

4: LAH / tetrahydrofuran / 3 h / 25 °C

5: K₂CO₃ / CHCl₃ / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; hydrogen; potassium carbonate; platinum(IV) oxide; In tetrahydrofuran; chloroform; water;
DOI:10.1021/jm00112a042

Reference yield:

: 135709-62-5
methyl quinoline-2-carboxylate hydrochloride

: 135709-59-0
2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-3,4-dihydro-2H-quinolin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / H₂, 20percent methanolic HCl / PtO₂ / 8 h / 775.7 Torr

2: 71 percent / H₂O / 15 h / Ambient temperature

3: LAH / tetrahydrofuran / 3 h / 25 °C

4: K₂CO₃ / CHCl₃ / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; potassium carbonate; platinum(IV) oxide; In tetrahydrofuran; chloroform; water;
DOI:10.1021/jm00112a042

Reference yield:

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 135709-59-0
2-(3,4-Dichloro-phenyl)-1-(2-pyrrolidin-1-ylmethyl-3,4-dihydro-2H-quinolin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride / CHCl₃ / Ambient temperature

2: K₂CO₃ / CHCl₃ / Ambient temperature

With oxalyl dichloride; potassium carbonate; In chloroform;
DOI:10.1021/jm00112a042