Technology Process of 5,6-bis(benzyloxy)-4-fluoroindole
There total 6 articles about 5,6-bis(benzyloxy)-4-fluoroindole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / Et3N, H2 / 10percent Pd/C / ethyl acetate / 5 h / 25 °C / 2068.6 Torr
2: 99 percent / BBr3 / CH2Cl2 / 1.) -78 deg C, 2 h, 2.) 25 deg C, 12 h
3: 75 percent / K2CO3, NaI / acetone / 12 h / Heating
4: 78 percent / 90percent HNO3, HOAc / 0.5 h / 25 °C
5: 3 h / 120 °C
6: Fe, silica gel, acetic acid / toluene / 1 h / Heating
With
hydrogen; nitric acid; silica gel; boron tribromide; iron; potassium carbonate; acetic acid; triethylamine; sodium iodide;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate; acetone; toluene;
DOI:10.1021/jm00170a026
- Guidance literature:
-
With
silica gel; iron; acetic acid;
In
toluene;
for 1h;
Yield given;
Heating;
DOI:10.1021/jm00170a026
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / BBr3 / CH2Cl2 / 1.) -78 deg C, 2 h, 2.) 25 deg C, 12 h
2: 75 percent / K2CO3, NaI / acetone / 12 h / Heating
3: 78 percent / 90percent HNO3, HOAc / 0.5 h / 25 °C
4: 3 h / 120 °C
5: Fe, silica gel, acetic acid / toluene / 1 h / Heating
With
nitric acid; silica gel; boron tribromide; iron; potassium carbonate; acetic acid; sodium iodide;
In
dichloromethane; acetone; toluene;
DOI:10.1021/jm00170a026
