3-Oxo-butyric acid (1R,2R,3S,5S)-3-(2-methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]hept-2-yl ester

Base Information

• Chemical Name: 3-Oxo-butyric acid (1R,2R,3S,5S)-3-(2-methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]hept-2-yl ester
• CAS No.: 198027-55-3
• Molecular Formula: C₂₁H₂₈O₄
• Molecular Weight: 344.451
• Mol file: 198027-55-3.mol

Synonyms:3-Oxo-butyric acid (1R,2R,3S,5S)-3-(2-methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]hept-2-yl ester

Chemical Property of 3-Oxo-butyric acid (1R,2R,3S,5S)-3-(2-methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]hept-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Oxo-butyric acid (1R,2R,3S,5S)-3-(2-methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]hept-2-yl ester

There total 1 articles about 3-Oxo-butyric acid (1R,2R,3S,5S)-3-(2-methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,6-trimethyl-4H-1,3-dioxin-4-one (5394-63-8) + (1R,2R,3S,5S)-3-(2-Methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]heptan-2-ol (188851-35-6) → acetone (67-64-1) + 3-Oxo-butyric acid (1R,2R,3S,5S)-3-(2-methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]hept-2-yl ester (198027-55-3)

Guidance literature:

In toluene; at 120 ℃; for 2h;

DOI:10.1080/00397910008087342

Reference yield: 80.0%

2-(3-indole)-ethanol (526-55-6,930395-07-6) + 3-Oxo-butyric acid (1R,2R,3S,5S)-3-(2-methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]hept-2-yl ester (198027-55-3) → (1-Methyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid (1R,2R,3S,5S)-3-(2-methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]hept-2-yl ester

Guidance literature:

With boron trifluoride diethyl etherate; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4039(97)01658-4

Reference yield:

3-Oxo-butyric acid (1R,2R,3S,5S)-3-(2-methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]hept-2-yl ester (198027-55-3) → (S)-3-Hydroxy-butyric acid (1R,2R,3S,5S)-3-(2-methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]hept-2-yl ester + (R)-3-Hydroxy-butyric acid (1R,2R,3S,5S)-3-(2-methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]hept-2-yl ester

Guidance literature:

With sodium tetrahydroborate; manganese(ll) chloride; In methanol; at 0 ℃; for 0.166667h; Title compound not separated from byproducts;

DOI:10.1080/00397910008087342

upstream raw materials:

2,2,6-trimethyl-4H-1,3-dioxin-4-one

(1R,2R,3S,5S)-3-(2-Methoxy-benzyl)-6,6-dimethyl-bicyclo[3.1.1]heptan-2-ol