2-bromo-3,5-dimethoxy-1-triisopropylsiloxymethylbenzene

Base Information

• Chemical Name: 2-bromo-3,5-dimethoxy-1-triisopropylsiloxymethylbenzene
• CAS No.: 409360-03-8
• Molecular Formula: C₁₈H₃₁BrO₃Si
• Molecular Weight: 403.432
• Mol file: 409360-03-8.mol

Synonyms:2-bromo-3,5-dimethoxy-1-triisopropylsiloxymethylbenzene

Chemical Property of 2-bromo-3,5-dimethoxy-1-triisopropylsiloxymethylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-3,5-dimethoxy-1-triisopropylsiloxymethylbenzene

There total 2 articles about 2-bromo-3,5-dimethoxy-1-triisopropylsiloxymethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

triisopropylsilyl chloride (13154-24-0) + 2-bromo-3,5-dimethoxybenzyl alcohol (74726-76-4) → 2-bromo-3,5-dimethoxy-1-triisopropylsiloxymethylbenzene (409360-03-8)

Guidance literature:

With 1-methyl-1H-imidazole; iodine; In dichloromethane; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201311299

Reference yield:

3,5-dimethoxybenzyl alcohol (705-76-0) → 2-bromo-3,5-dimethoxy-1-triisopropylsiloxymethylbenzene (409360-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / dichloromethane / 12.5 h / 0 - 25 °C / Inert atmosphere

2: 1-methyl-1H-imidazole / dichloromethane / 1 h / 25 °C / Inert atmosphere

With 1-methyl-1H-imidazole; N-Bromosuccinimide; In dichloromethane;

DOI:10.1021/ol501284s

Reference yield: 98.0%

2-bromo-3,5-dimethoxy-1-triisopropylsiloxymethylbenzene (409360-03-8) → 2,4-dimethoxy-6-triisopropylsiloxymethylphenylboronic acid (409359-98-4)

Guidance literature:

2-bromo-3,5-dimethoxy-1-triisopropylsiloxymethylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; hexane; at 20 ℃; for 0.5h; Further stages.;

upstream raw materials:

triisopropylsilyl chloride

2-bromo-3,5-dimethoxybenzyl alcohol

3,5-dimethoxybenzyl alcohol

Downstream raw materials:

2,4-dimethoxy-6-triisopropylsiloxymethylphenylboronic acid

3,5-dimethoxy-2-trimethylstannanyl-1-triisopropylsiloxymethylbenzene