ethyl 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylate

Base Information

Chemical Name:ethyl 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylate
CAS No.:1159318-50-9
Molecular Formula:C₂₁H₃₀N₂O₄
Molecular Weight:374.48
Hs Code.:

Synonyms:ethyl 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylate

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Chemical Property of ethyl 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylate

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Technology Process of ethyl 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylate

There total 4 articles about ethyl 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 15159-40-7
4-morpholinocarbonyl chloride

: 1159317-82-4
ethyl 5-(4-ethylphenyl)piperidine-3-carboxylate

: 1159318-50-9
ethyl 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 20986-40-7
ethyl 5-bromo-3-pyridinecarboxylate

: 1159318-50-9
ethyl 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / Inert atmosphere; Reflux

2: hydrogen / palladium on activated charcoal / ethanol / 60 °C / 37503.8 Torr / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With potassium fluoride; hydrogen; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In ethanol; dichloromethane; toluene;

Reference yield:

: 1159317-80-2
ethyl 5-(4-ethylphenyl)pyridine-3-carboxylate

: 1159318-50-9
ethyl 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on activated charcoal / ethanol / 60 °C / 37503.8 Torr / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane;