Imidazo[1,5-a]pyrazine,5,6,7,8-tetrahydro-

Base Information

• Chemical Name: Imidazo[1,5-a]pyrazine,5,6,7,8-tetrahydro-
• CAS No.: 297172-19-1
• Molecular Formula: C6H9N3
• Molecular Weight: 123.1558
• Hs Code.: 2933990090
• Mol file: 297172-19-1.mol

Synonyms:5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine;imidazo[1,5-a]pyrazine, 5,6,7,8-tetrahydro-;

Chemical Property of Imidazo[1,5-a]pyrazine,5,6,7,8-tetrahydro-

Chemical Property:

• Vapor Pressure: 8.84E-05mmHg at 25°C
• Refractive Index: 1.689
• Boiling Point: 340 °C at 760 mmHg
• PKA: 8.26±0.20(Predicted)
• Flash Point: 159.4 °C
• PSA: 29.85000
• Density: 1.33 g/cm³
• LogP: 0.31510
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

5,6,7,8-Tetrahydroimidazo[1,5-A]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5,6,7,8-Tetrahydroimidazo[1,5-A]pyrazine can be used as KRAS G12C inhibitors as antitumor agents.

Technology Process of Imidazo[1,5-a]pyrazine,5,6,7,8-tetrahydro-

There total 1 articles about Imidazo[1,5-a]pyrazine,5,6,7,8-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine (165894-09-7) → 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine (297172-19-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; under 750.075 Torr;

Reference yield: 53.0%

5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine (297172-19-1) + (4-nitrophenyl)ethyl bromide (5339-26-4) → 7-(4-nitrophenethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 6h;

DOI:10.1021/acs.jmedchem.1c01272

Reference yield:

5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine (297172-19-1) + C12H10Cl2N2O2 (1152560-16-1) → C18H17Cl2N5O2 (1424330-28-8)

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 30 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.12.076

upstream raw materials:

7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

Downstream raw materials:

5-[5,6-dihydroimidazo[1,5-a]pyrazin-7(8H)-yl]-3-(2-fluorophenyl)-[1,2,3]triazolo[1,5-a]quinazoline

C₁₈H₁₇Cl₂N₅O₂

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