1-(4,8-Dimethylnona-3,7-dien-1-YL)-4-methoxybenzene

Base Information

• Chemical Name: 1-(4,8-Dimethylnona-3,7-dien-1-YL)-4-methoxybenzene
• CAS No.: 38011-83-5
• Molecular Formula: C18H26O
• Molecular Weight: 258.404
• DSSTox Substance ID: DTXSID80706891
• Mol file: 38011-83-5.mol

Synonyms:38011-83-5;DTXSID80706891;1-(4,8-DIMETHYLNONA-3,7-DIEN-1-YL)-4-METHOXYBENZENE

Chemical Property of 1-(4,8-Dimethylnona-3,7-dien-1-YL)-4-methoxybenzene

Chemical Property:

• PSA: 9.23000
• LogP: 5.32050
• XLogP3: 6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 7
• Exact Mass: 258.198365449
• Heavy Atom Count: 19
• Complexity: 289

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=CCCC(=CCCC1=CC=C(C=C1)OC)C)C

Technology Process of 1-(4,8-Dimethylnona-3,7-dien-1-YL)-4-methoxybenzene

There total 12 articles about 1-(4,8-Dimethylnona-3,7-dien-1-YL)-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,7-dimethyl-2E,6-octadien-1-yl acetate (105-87-3,8022-83-1) + p-methoxybenzyl chloride (824-94-2) → trans-1-(4,8-dimethylnona-3,7-dien-1-yl)-4-methoxybenzene (38011-83-5)

Guidance literature:

p-methoxybenzyl chloride; With magnesium; ethylene dibromide; In tetrahydrofuran; at 0 - 25 ℃; Inert atmosphere;

3,7-dimethyl-2E,6-octadien-1-yl acetate; With lithium chloride; copper dichloride; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; iso-butanol; at -10 - 0 ℃; for 3.33333h; Inert atmosphere;

DOI:10.1021/jacs.8b01660

Reference yield: 92.0%

3,7-dimethyl-2E,6-octadien-1-yl acetate (105-87-3,8022-83-1) + 4-methoxybenzylmagnesium chloride (38769-92-5) → trans-1-(4,8-dimethylnona-3,7-dien-1-yl)-4-methoxybenzene (38011-83-5)

Guidance literature:

With dilithium tetrachlorocuprate; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/j.ejmech.2018.04.032

Reference yield: 91.0%

(E)-3,7-dimethylocta-2,6-dien-1-yl diethyl phosphate (60699-32-3) + p-methoxybenzyl chloride (824-94-2) → p-methylanizole (104-93-8) + trans-1-(4,8-dimethylnona-3,7-dien-1-yl)-4-methoxybenzene (38011-83-5)

Guidance literature:

p-methoxybenzyl chloride; With magnesium; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

(E)-3,7-dimethylocta-2,6-dien-1-yl diethyl phosphate; In tetrahydrofuran; at -40 - 25 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.200903834

upstream raw materials:

p-methoxybenzyl chloride

1-chloro-3,7-dimethylocta-2,6-diene

geranyl phenyl sulfide

trans-geranyl bromide

Downstream raw materials:

(E)-4-(4,8-dimethylnona-3,7-dien-1-yl)phenol

sugiol

(+/-)-ferruginol

4-((E)-4,8-Dimethyl-nona-3,7-dienyl)-1,2-dimethoxy-benzene