1-methyl-4-<2-<1-(4-methoxyphenylsulfonyl)-2-indolyl>-1,3-dithian-2-yl>-4-piperidinol

Base Information

Chemical Name:1-methyl-4-<2-<1-(4-methoxyphenylsulfonyl)-2-indolyl>-1,3-dithian-2-yl>-4-piperidinol
CAS No.:128721-21-1
Molecular Formula:C₂₅H₃₀N₂O₄S₃
Molecular Weight:518.722
Hs Code.:

Synonyms:1-methyl-4-<2-<1-(4-methoxyphenylsulfonyl)-2-indolyl>-1,3-dithian-2-yl>-4-piperidinol

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Chemical Property of 1-methyl-4-<2-<1-(4-methoxyphenylsulfonyl)-2-indolyl>-1,3-dithian-2-yl>-4-piperidinol

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Technology Process of 1-methyl-4-<2-<1-(4-methoxyphenylsulfonyl)-2-indolyl>-1,3-dithian-2-yl>-4-piperidinol

There total 5 articles about 1-methyl-4-<2-<1-(4-methoxyphenylsulfonyl)-2-indolyl>-1,3-dithian-2-yl>-4-piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-72-9
indole

: 128721-21-1
1-methyl-4-<2-<1-(4-methoxyphenylsulfonyl)-2-indolyl>-1,3-dithian-2-yl>-4-piperidinol

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / tetrabutylammonium hydrogensulfate, 50percent aq. NaOH / benzene / 16 h / Ambient temperature

2: 1.) diisopropylamine, n-butyllithium / 1.) THF, 0 deg C, 30 min, 2.) RT, 5 h

3: 95 percent / p-toluenesulfonic acid / toluene / 15 h / Heating

4: 1.) n-butyllithium / 1.) THF, -40 deg C, 15 min, 2.) -40 deg C, 45 min

With sodium hydroxide; n-butyllithium; tetra(n-butyl)ammonium hydrogensulfate; toluene-4-sulfonic acid; diisopropylamine; In toluene; benzene;
DOI:10.3987/COM-89-5240

Reference yield:

: 128721-40-4
1-((4-methoxyphenyl)sulfonyl)-1H-indole

: 128721-21-1
1-methyl-4-<2-<1-(4-methoxyphenylsulfonyl)-2-indolyl>-1,3-dithian-2-yl>-4-piperidinol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) diisopropylamine, n-butyllithium / 1.) THF, 0 deg C, 30 min, 2.) RT, 5 h

2: 95 percent / p-toluenesulfonic acid / toluene / 15 h / Heating

3: 1.) n-butyllithium / 1.) THF, -40 deg C, 15 min, 2.) -40 deg C, 45 min

With n-butyllithium; toluene-4-sulfonic acid; diisopropylamine; In toluene;
DOI:10.3987/COM-89-5240

Reference yield:

: 128721-41-5
1-(4-methoxyphenylsulfonyl)indole-2-carbaldehyde

: 128721-21-1
1-methyl-4-<2-<1-(4-methoxyphenylsulfonyl)-2-indolyl>-1,3-dithian-2-yl>-4-piperidinol

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / p-toluenesulfonic acid / toluene / 15 h / Heating

2: 1.) n-butyllithium / 1.) THF, -40 deg C, 15 min, 2.) -40 deg C, 45 min

With n-butyllithium; toluene-4-sulfonic acid; In toluene;
DOI:10.3987/COM-89-5240