methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(2-cyanoethyl)-6-phenyl-2-methoxycarbonyl-4-oxohexanoate

Base Information

Chemical Name:methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(2-cyanoethyl)-6-phenyl-2-methoxycarbonyl-4-oxohexanoate
CAS No.:119706-41-1
Molecular Formula:C₂₆H₂₈N₂O₇
Molecular Weight:480.518
Hs Code.:

Synonyms:methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(2-cyanoethyl)-6-phenyl-2-methoxycarbonyl-4-oxohexanoate

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Chemical Property of methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(2-cyanoethyl)-6-phenyl-2-methoxycarbonyl-4-oxohexanoate

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Technology Process of methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(2-cyanoethyl)-6-phenyl-2-methoxycarbonyl-4-oxohexanoate

There total 1 articles about methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(2-cyanoethyl)-6-phenyl-2-methoxycarbonyl-4-oxohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 116835-54-2
2-((S)-3-Benzyloxycarbonylamino-2-oxo-4-phenyl-butyl)-malonic acid dimethyl ester

: 107-13-1,25014-41-9
acrylonitrile

: 119706-41-1
methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(2-cyanoethyl)-6-phenyl-2-methoxycarbonyl-4-oxohexanoate

Guidance literature:: With sodium methylate; In methanol; for 3h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86018-X

Reference yield:

: 119706-41-1
methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(2-cyanoethyl)-6-phenyl-2-methoxycarbonyl-4-oxohexanoate

: 119706-52-4,119706-53-5
HCl*Z-Phe γ(COCH2)(RS)Orn

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 6N NaOH / 1.) methanol, room t., 3 h; 2.) dioxane, reflux, 4 h

2: 70 percent / hydrogen, ammonia / Raney nickel / methanol / 7 h / 2068.6 Torr / Ambient temperature

With sodium hydroxide; ammonia; hydrogen; nickel; In methanol;
DOI:10.1016/S0040-4020(01)86018-X

Reference yield:

: 119706-41-1
methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(2-cyanoethyl)-6-phenyl-2-methoxycarbonyl-4-oxohexanoate

: 119706-56-8,119706-57-9
HCl*Z-Trp ψ(COCH2)(RS)Arg

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 6N NaOH / 1.) methanol, room t., 3 h; 2.) dioxane, reflux, 4 h

2: 70 percent / hydrogen, ammonia / Raney nickel / methanol / 7 h / 2068.6 Torr / Ambient temperature

3: 63.5 percent / triethylamine / dimethylformamide / 168 h / Ambient temperature; pH: 8-9

With sodium hydroxide; ammonia; hydrogen; triethylamine; nickel; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86018-X