tert-butyl 2-methoxy-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

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Chemical Name:tert-butyl 2-methoxy-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate
CAS No.:1428790-27-5
Molecular Formula:C₂₇H₃₅F₃N₄O₄
Molecular Weight:536.595
Hs Code.:

Synonyms:tert-butyl 2-methoxy-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

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Chemical Property of tert-butyl 2-methoxy-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

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Technology Process of tert-butyl 2-methoxy-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

There total 7 articles about tert-butyl 2-methoxy-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1428790-26-4
2-(4-cyano-3-methoxyphenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

: 1428790-27-5
tert-butyl 2-methoxy-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

Guidance literature:: di-tert-butyl dicarbonate; 2-(4-cyano-3-methoxyphenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide; With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; at 0 - 23 ℃; for 1h;

With 3-azapentane-1,5-diamine; for 1h;

Reference yield:

: 91-23-6
2-Nitroanisole

: 1428790-27-5
tert-butyl 2-methoxy-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / -30 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 15 h

3.1: sodium nitrite; potassium iodide

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 36 h / 120 °C

5.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

6.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; triethylamine / acetonitrile / 15 h / 20 °C

7.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 20 °C

7.2: 1 h

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; potassium iodide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1402585-28-7
ethyl 2-(4-iodo-3-methoxyphenyl)propanoate

: 1428790-27-5
tert-butyl 2-methoxy-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 36 h / 120 °C

2.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

3.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; triethylamine / acetonitrile / 15 h / 20 °C

4.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 20 °C

4.2: 1 h

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride hexahydrate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;