(3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-3-(4-phenylthiophen-2-yl)propyl)-N-tertbutyldecahydroisoquinoline-3-carboxamide

Base Information

Chemical Name:(3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-3-(4-phenylthiophen-2-yl)propyl)-N-tertbutyldecahydroisoquinoline-3-carboxamide
CAS No.:1208246-91-6
Molecular Formula:C₂₇H₃₉N₃O₂S
Molecular Weight:469.692
Hs Code.:

Synonyms:(3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-3-(4-phenylthiophen-2-yl)propyl)-N-tertbutyldecahydroisoquinoline-3-carboxamide

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Chemical Property of (3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-3-(4-phenylthiophen-2-yl)propyl)-N-tertbutyldecahydroisoquinoline-3-carboxamide

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Technology Process of (3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-3-(4-phenylthiophen-2-yl)propyl)-N-tertbutyldecahydroisoquinoline-3-carboxamide

There total 1 articles about (3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-3-(4-phenylthiophen-2-yl)propyl)-N-tertbutyldecahydroisoquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1208246-88-1
(3S,4aS,8aS)-2-((2R,3R)-3-azido-2-hydroxy-3-(4-phenylthiophen-2-yl)propyl)-N-tertbutyldecahydroisoquinoline-3-carboxamide

: 1208246-91-6
(3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-3-(4-phenylthiophen-2-yl)propyl)-N-tertbutyldecahydroisoquinoline-3-carboxamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h; under 760.051 Torr;
DOI:10.1021/jm900846f

Reference yield: 61.0%

: 1208246-91-6
(3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-3-(4-phenylthiophen-2-yl)propyl)-N-tertbutyldecahydroisoquinoline-3-carboxamide

: 168899-58-9
3-acetoxy-2-methylbenzoic acid

: 1208246-94-9
3-((1R,2R)-3-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-2-hydroxy-1-(4-phenylthiophen-2-yl)propylcarbamoyl)-2-methylphenyl acetate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm900846f

Reference yield: 60.0%

: 1208246-91-6
(3S,4aS,8aS)-2-((2R,3R)-3-amino-2-hydroxy-3-(4-phenylthiophen-2-yl)propyl)-N-tertbutyldecahydroisoquinoline-3-carboxamide

: 136465-98-0
(2S)-2-[(quinoline-2-carbonyl)-amino]-succinamic acid

: (S)-N₁-((1R,2R)-3-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2-(1H)-yl)-2-hydroxy-1-(4-phenylthiophen-2-yl)propyl)-2-(quinoline-2-carboxamido)succinamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm900846f