3',4'-anhydro-4'',6''-O-cyclohexylidene-4'-epi-1,3,2',6',3''-penta-N-tosylkanamycin B

Base Information

Chemical Name:3',4'-anhydro-4'',6''-O-cyclohexylidene-4'-epi-1,3,2',6',3''-penta-N-tosylkanamycin B
CAS No.:144218-77-9
Molecular Formula:C₅₉H₇₃N₅O₁₉S₅
Molecular Weight:1316.58
Hs Code.:

Synonyms:3',4'-anhydro-4'',6''-O-cyclohexylidene-4'-epi-1,3,2',6',3''-penta-N-tosylkanamycin B

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Chemical Property of 3',4'-anhydro-4'',6''-O-cyclohexylidene-4'-epi-1,3,2',6',3''-penta-N-tosylkanamycin B

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Technology Process of 3',4'-anhydro-4'',6''-O-cyclohexylidene-4'-epi-1,3,2',6',3''-penta-N-tosylkanamycin B

There total 1 articles about 3',4'-anhydro-4'',6''-O-cyclohexylidene-4'-epi-1,3,2',6',3''-penta-N-tosylkanamycin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 144218-76-8
4'-O-benzylsulfonyl-4'',6''-O-cyclohexylidene-1,3,2',6',3''-penta-N-tosylkanamycin B

: 144218-77-9
3',4'-anhydro-4'',6''-O-cyclohexylidene-4'-epi-1,3,2',6',3''-penta-N-tosylkanamycin B

Guidance literature:: With sodium methylate; In methanol; for 0.5h; Ambient temperature;
DOI:10.1016/S0008-6215(00)90996-0

Reference yield: 52.0%

: 107-21-1
ethylene glycol

: 144218-77-9
3',4'-anhydro-4'',6''-O-cyclohexylidene-4'-epi-1,3,2',6',3''-penta-N-tosylkanamycin B

: 144218-79-1
6'-deamino-3'-deoxy-4'-epi-1,3,2',3''-tetra-N-tosyl-3',6'-(N-tosylepimino)kanamycin B

: 144218-80-4
3'-deoxy-4'-epi-3'-fluoro-1,3,2',6',3''-penta-N-tosylkanamycin B

: 144218-78-0
4'-deoxy-4'-fluoro-1,3,2',6',3''-penta-N-tosylkanamycin B

Guidance literature:: With potassium hydrogen bifluoride; at 150 ℃; for 4h; Mechanism; other 3',4'-anhydro-4'-epi-N-tosylkanamycin; other reaction time;
DOI:10.1016/S0008-6215(00)90996-0

Reference yield:

: 144218-77-9
3',4'-anhydro-4'',6''-O-cyclohexylidene-4'-epi-1,3,2',6',3''-penta-N-tosylkanamycin B

: 144539-57-1
4'-deoxy-4'-fluorokanamycin B carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: 24 percent / KHF₂ / ethane-1,2-diol / 4 h / 150 °C

2: 53 percent / Na, NH₃(liquid) / -60 °C

With potassium hydrogen bifluoride; ammonia; sodium; In ethylene glycol;
DOI:10.1016/S0008-6215(00)90996-0