tert-butyl N-{2-[N-(prop-2'-yn-1'-yl)-2-nitrophenylsulfonamido]ethyl}carbamate

Base Information

Chemical Name:tert-butyl N-{2-[N-(prop-2'-yn-1'-yl)-2-nitrophenylsulfonamido]ethyl}carbamate
CAS No.:862120-81-8
Molecular Formula:C₁₆H₂₁N₃O₆S
Molecular Weight:383.425
Hs Code.:

Synonyms:tert-butyl N-{2-[N-(prop-2'-yn-1'-yl)-2-nitrophenylsulfonamido]ethyl}carbamate

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Chemical Property of tert-butyl N-{2-[N-(prop-2'-yn-1'-yl)-2-nitrophenylsulfonamido]ethyl}carbamate

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Technology Process of tert-butyl N-{2-[N-(prop-2'-yn-1'-yl)-2-nitrophenylsulfonamido]ethyl}carbamate

There total 7 articles about tert-butyl N-{2-[N-(prop-2'-yn-1'-yl)-2-nitrophenylsulfonamido]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 106-96-7
propargyl bromide

: 214000-16-5
N-(tert-butoxycarbonyl)-N'-(2-nitrobenzenesulfonyl)ethylenediamine

: 862120-81-8
tert-butyl N-{2-[N-(prop-2'-yn-1'-yl)-2-nitrophenylsulfonamido]ethyl}carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.tetlet.2009.04.094

Reference yield:

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

: 862120-81-8
tert-butyl N-{2-[N-(prop-2'-yn-1'-yl)-2-nitrophenylsulfonamido]ethyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride; triethylamine; 1H-imidazole / dichloromethane / -60 °C / Inert atmosphere

1.2: 0 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

2.3: 1 h

With 1H-imidazole; thionyl chloride; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol402988s

Reference yield:

: 198572-71-3
N-(tert-butoxycarbonyl)-2-nitrobenzenesulfonamide

: 862120-81-8
tert-butyl N-{2-[N-(prop-2'-yn-1'-yl)-2-nitrophenylsulfonamido]ethyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

2.3: 1 h

With sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol402988s