N-<4-(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-2(S)-isopropylhexanoyl>-2(S)-methylbutylamine

Base Information

Chemical Name:N-<4-(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-2(S)-isopropylhexanoyl>-2(S)-methylbutylamine
CAS No.:124322-05-0
Molecular Formula:C₃₁H₆₂N₂O₄Si
Molecular Weight:554.93
Hs Code.:

Synonyms:N-<4-(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-2(S)-isopropylhexanoyl>-2(S)-methylbutylamine

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Chemical Property of N-<4-(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-2(S)-isopropylhexanoyl>-2(S)-methylbutylamine

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Technology Process of N-<4-(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-2(S)-isopropylhexanoyl>-2(S)-methylbutylamine

There total 1 articles about N-<4-(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-2(S)-isopropylhexanoyl>-2(S)-methylbutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 34985-37-0
(S)-2-methylbutylamine

: 123471-30-7
4(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-2(S)-isopropylhexanoic acid

: 124322-05-0
N-<4-(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-2(S)-isopropylhexanoyl>-2(S)-methylbutylamine

Guidance literature:: With diethylphosphoryl cyanide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 3h;
DOI:10.1021/jm00108a006

Reference yield:

: 124322-05-0
N-<4-(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-2(S)-isopropylhexanoyl>-2(S)-methylbutylamine

: 124344-07-6
(S)-N-[(1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-4-((S)-2-methyl-butylcarbamoyl)-hexyl]-2-(2-phenoxy-acetoxy)-succinamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid (TFA) / CH₂Cl₂ / 0.75 h / Ambient temperature

2: diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / Ambient temperature

3: 4-(dimethylamino)pyridine / CH₂Cl₂ / Ambient temperature

4: trifluoroacetic acid (TFA) / CH₂Cl₂ / 1 h / Ambient temperature

5: H₂ / 5percent Pd/C / methanol / 2 h / 2585.7 Torr

With dmap; diethylphosphoryl cyanide; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00167a009

Reference yield:

: 124322-05-0
N-<4-(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-6-cyclohexyl-2(S)-isopropylhexanoyl>-2(S)-methylbutylamine

: 124321-85-3
(S)-N-[(1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-4-((S)-2-methyl-butylcarbamoyl)-hexyl]-2-(2-phenoxy-acetylamino)-succinamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: HCl (gas) / diethyl ether / 0.25 h

2: diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂ / Ambient temperature

3: trifluoroacetic acid (TFA) / CH₂Cl₂ / 0.75 h / Ambient temperature

4: diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂ / overnight

5: ammonium formate / 10percent Pd/C / dimethylformamide / 3 h / Ambient temperature

With hydrogenchloride; diethylphosphoryl cyanide; ammonium formate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a009