3-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}-2-methylpropanoic acid hydrochloride

Base Information

Chemical Name:3-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}-2-methylpropanoic acid hydrochloride
CAS No.:1355084-90-0
Molecular Formula:C₂₃H₂₅Cl₂NO₄*ClH
Molecular Weight:486.823
Hs Code.:

Synonyms:3-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}-2-methylpropanoic acid hydrochloride

Suppliers and Price of 3-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}-2-methylpropanoic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}-2-methylpropanoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}-2-methylpropanoic acid hydrochloride

There total 10 articles about 3-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}-2-methylpropanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: C₂₇H₃₃Cl₂NO₄

: 1355084-90-0
3-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}-2-methylpropanoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 48h;
DOI:10.1016/j.bmcl.2017.12.018

Reference yield:

: 1355089-15-4
tert-butyl 3-{6-hydroxy-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}-2-methyl-propanoate

: 1355084-90-0
3-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}-2-methylpropanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 16 h / 20 °C

2: hydrogenchloride / water; 1,4-dioxane / 48 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; dichloromethane; water; 1: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2017.12.018

Reference yield:

: 1355087-61-4
1'-benzyl-2H-spiro(1-benzofuran-3,4'-piperidin)-6-ol

: 1355084-90-0
3-{6-[(2,6-dichlorophenyl)methoxy]-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-yl}-2-methylpropanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium(II) hydroxide; hydrogenchloride / water; methanol / 48 h / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 16 h / 140 °C / Sealed tube

3: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 16 h / 20 °C

4: hydrogenchloride / water; 1,4-dioxane / 48 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; hydrogen; palladium(II) hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 3: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2017.12.018