2-<2-<4-<(4-carboxy-1-oxobutyl)amino>phenyl>-1-hydroxyethyl>benzoic acid

Base Information

Chemical Name:2-<2-<4-<(4-carboxy-1-oxobutyl)amino>phenyl>-1-hydroxyethyl>benzoic acid
CAS No.:134485-46-4
Molecular Formula:C₂₀H₂₁NO₆
Molecular Weight:371.39
Hs Code.:

Synonyms:2-<2-<4-<(4-carboxy-1-oxobutyl)amino>phenyl>-1-hydroxyethyl>benzoic acid

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Chemical Property of 2-<2-<4-<(4-carboxy-1-oxobutyl)amino>phenyl>-1-hydroxyethyl>benzoic acid

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Technology Process of 2-<2-<4-<(4-carboxy-1-oxobutyl)amino>phenyl>-1-hydroxyethyl>benzoic acid

There total 9 articles about 2-<2-<4-<(4-carboxy-1-oxobutyl)amino>phenyl>-1-hydroxyethyl>benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 108-55-4
glutaric anhydride,

: 137998-66-4
2-<2-(4-aminophenyl)-1-hydroxyethyl>benzoic acid

: 134485-46-4
2-<2-<4-<(4-carboxy-1-oxobutyl)amino>phenyl>-1-hydroxyethyl>benzoic acid

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1021/ja00014a039

Reference yield:

: 1460-05-5
p-nitrophenylacetaldehyde

: 134485-46-4
2-<2-<4-<(4-carboxy-1-oxobutyl)amino>phenyl>-1-hydroxyethyl>benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / Rexyn 101 (H) cation-exchange resin, CaSO₄ / CH₂Cl₂ / 24 h / Ambient temperature

2: 95 percent / H₂ / 10percent Pd/C / methanol / 6 h / Ambient temperature

3: 80 percent / Et₃N / CH₂Cl₂ / 1 h

4: 40 percent / 4 M HCl / acetone / 24 h / Ambient temperature

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C, 4 h

6: 95 percent / H₂ / 10percent Pd/C / methanol / 1.5 h

7: 80 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; calcium sulfate; n-butyllithium; Rexyn 101 (H) cation-exchange resin; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetone;
DOI:10.1021/ja00014a039

Reference yield:

: 100-13-0
4-nitrostyrene

: 134485-46-4
2-<2-<4-<(4-carboxy-1-oxobutyl)amino>phenyl>-1-hydroxyethyl>benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 50 percent / Pb(OAc)4, TFA / CH₂Cl₂ / 3 h / Ambient temperature

2: 60 percent / Rexyn 101 (H) cation-exchange resin, CaSO₄ / CH₂Cl₂ / 24 h / Ambient temperature

3: 95 percent / H₂ / 10percent Pd/C / methanol / 6 h / Ambient temperature

4: 80 percent / Et₃N / CH₂Cl₂ / 1 h

5: 40 percent / 4 M HCl / acetone / 24 h / Ambient temperature

6: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C, 4 h

7: 95 percent / H₂ / 10percent Pd/C / methanol / 1.5 h

8: 80 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With lead(IV) acetate; hydrogenchloride; calcium sulfate; n-butyllithium; Rexyn 101 (H) cation-exchange resin; hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; acetone;
DOI:10.1021/ja00014a039