tert-butyl (2-((4-bromo-2-(hydroxymethyl)phenyl)ethynyl)phenyl)carbamate

Base Information

Chemical Name:tert-butyl (2-((4-bromo-2-(hydroxymethyl)phenyl)ethynyl)phenyl)carbamate
CAS No.:1616954-95-0
Molecular Formula:C₂₀H₂₀BrNO₃
Molecular Weight:402.288
Hs Code.:

Synonyms:tert-butyl (2-((4-bromo-2-(hydroxymethyl)phenyl)ethynyl)phenyl)carbamate

Suppliers and Price of tert-butyl (2-((4-bromo-2-(hydroxymethyl)phenyl)ethynyl)phenyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (2-((4-bromo-2-(hydroxymethyl)phenyl)ethynyl)phenyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2-((4-bromo-2-(hydroxymethyl)phenyl)ethynyl)phenyl)carbamate

There total 4 articles about tert-butyl (2-((4-bromo-2-(hydroxymethyl)phenyl)ethynyl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1616954-90-5
(2-((2-aminophenyl)ethynyl)-5-bromophenyl)methanol

: 1616954-95-0
tert-butyl (2-((4-bromo-2-(hydroxymethyl)phenyl)ethynyl)phenyl)carbamate

Guidance literature:: In tetrahydrofuran; at 70 ℃; for 48h; Sealed tube;
DOI:10.1039/c4ob00694a

Reference yield:

: 199786-58-8
(5-bromo-2-iodo-phenyl)-methanol

: 1616954-95-0
tert-butyl (2-((4-bromo-2-(hydroxymethyl)phenyl)ethynyl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 16 h / Inert atmosphere; Schlenk technique

2: tetrahydrofuran / 48 h / 70 °C / Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; 1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4ob00694a

Reference yield:

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 1616954-95-0
tert-butyl (2-((4-bromo-2-(hydroxymethyl)phenyl)ethynyl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; sodium nitrite / dimethyl sulfoxide / 1 h / 20 °C

1.2: 2 h

2.1: triethylamine; chloroformic acid ethyl ester / 1 h / 0 °C

2.2: 1.5 h

3.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 16 h / Inert atmosphere; Schlenk technique

4.1: tetrahydrofuran / 48 h / 70 °C / Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; chloroformic acid ethyl ester; triethylamine; sodium nitrite; In tetrahydrofuran; dimethyl sulfoxide; 3.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4ob00694a