3-[3-(2-Amino-phenyl)-5-butyl-1,4-dimethyl-1H-pyrrol-2-yl]-propionic acid

Base Information

Chemical Name:3-[3-(2-Amino-phenyl)-5-butyl-1,4-dimethyl-1H-pyrrol-2-yl]-propionic acid
CAS No.:180338-23-2
Molecular Formula:C₁₉H₂₆N₂O₂
Molecular Weight:314.428
Hs Code.:

Synonyms:3-[3-(2-Amino-phenyl)-5-butyl-1,4-dimethyl-1H-pyrrol-2-yl]-propionic acid

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Chemical Property of 3-[3-(2-Amino-phenyl)-5-butyl-1,4-dimethyl-1H-pyrrol-2-yl]-propionic acid

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Technology Process of 3-[3-(2-Amino-phenyl)-5-butyl-1,4-dimethyl-1H-pyrrol-2-yl]-propionic acid

There total 8 articles about 3-[3-(2-Amino-phenyl)-5-butyl-1,4-dimethyl-1H-pyrrol-2-yl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (E)-3-[5-Butyl-1,4-dimethyl-3-(2-nitro-phenyl)-1H-pyrrol-2-yl]-acrylic acid

: 180338-23-2
3-[3-(2-Amino-phenyl)-5-butyl-1,4-dimethyl-1H-pyrrol-2-yl]-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 3h; under 760 Torr;

Reference yield:

: 129044-98-0
1,4-dimethyl-3-(2'-nitrophenyl)pyrrole-2-carboxylate d'ethyle

: 180338-23-2
3-[3-(2-Amino-phenyl)-5-butyl-1,4-dimethyl-1H-pyrrol-2-yl]-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / MgSO₄, HCl / tetrahydrofuran / Ambient temperature

2: 90 percent / soda / methanol / 1 h / 60 °C

3: 90 percent / Cu₂O / quinoline / 1 h / 175 °C

4: 90 percent / H₂ / 10percent Pd/C / ethyl acetate / 1 h / 2280 Torr

5: 90 percent / DMF / CH₂Cl₂ / 3 h / -40 °C

6: 85 percent / NaH / 1,2-dimethoxy-ethane / 3 h / Ambient temperature

7: 93 percent / NaOH / H₂O; methanol / 0.25 h / 60 °C

8: 90 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr

With copper(I) oxide; hydrogenchloride; sodium hydroxide; hydrogen; sodium hydride; sodium carbonate; magnesium sulfate; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; quinoline; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 139984-63-7
2-butyl-1,3-dimethyl-4-(2-nitrophenyl)-1H-pyrrole

: 180338-23-2
3-[3-(2-Amino-phenyl)-5-butyl-1,4-dimethyl-1H-pyrrol-2-yl]-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / DMF / CH₂Cl₂ / 3 h / -40 °C

2: 85 percent / NaH / 1,2-dimethoxy-ethane / 3 h / Ambient temperature

3: 93 percent / NaOH / H₂O; methanol / 0.25 h / 60 °C

4: 90 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 760 Torr

With sodium hydroxide; hydrogen; sodium hydride; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;