129044-98-0

Upstream product

• 80-48-8 methyl p-toluene sulfonate 
• 129044-97-9 4-methyl-3-(2'-nitrophenyl)pyrrole-2-carboxylate d'ethyle 
• 18982-46-2 1-nitro-2-[2-nitroprop-1-en-1-yl]benzene 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 129045-00-7 1,4-dimethyl-3-(2'-nitrophenyl)pyrrole-2-methanol 
• 129044-99-1 acide 1,4-dimethyl-3-(2-nitrophenyl)-1H-pyrrole-2-carboxylique 
• 180338-24-3 1,4-dimethyl-3-(2-nitrophenyl)-1H-pyrrole 
• 139984-63-7 2-butyl-1,3-dimethyl-4-(2-nitrophenyl)-1H-pyrrole 
• 180338-34-5 4-[3-(2-Amino-phenyl)-1,4-dimethyl-1H-pyrrol-2-yl]-butyric acid 
• 180338-28-7 1,3-Dimethyl-4-(2-nitro-phenyl)-1H-pyrrole-2-carboxylic acid 
• 180338-19-6 [3-(2-Amino-phenyl)-5-butyl-1,4-dimethyl-1H-pyrrol-2-yl]-acetic acid 
• 180338-29-8 1,3-Dimethyl-4-(2-nitro-phenyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 180338-13-0 5-butyl-1,4-dimethyl-3-(2-nitrophenyl)-1H-pyrrole-2-carbaldehyde 
• 180338-23-2 3-[3-(2-Amino-phenyl)-5-butyl-1,4-dimethyl-1H-pyrrol-2-yl]-propionic acid 
• 180338-33-4 4-[1,4-Dimethyl-3-(2-nitro-phenyl)-1H-pyrrol-2-yl]-butyric acid 
• 139984-66-0 4-[3-(2-Amino-phenyl)-5-butyl-1,4-dimethyl-1H-pyrrol-2-yl]-butyric acid 
• 180338-16-3 [5-Butyl-1,4-dimethyl-3-(2-nitro-phenyl)-1H-pyrrol-2-yl]-acetic acid 
• 180338-27-6 1-[1,3-Dimethyl-4-(2-nitro-phenyl)-1H-pyrrol-2-yl]-2,2,2-trifluoro-ethanone 

Relevant academic research and scientific papers

Compounds interacting with tubulin: Part I: Synthesis of ortho-ortho' substituted phenylpyrroles with free or restricted rotation.

The synthesis of ortho-ortho' substituted phenylpyrroles that are susceptible to isomerization of the biaryl type (atropisomerism) was performed using a Michael addition of isocyanoacetates with nitrostyrenes.Atropisomerism in phenylpyrroles 14 and 15 was studied by means of 1H NMR spectroscopy using chiral lanthanide shift reagents (LSR*).In the case of chiral phenylpyrrole 21, an evaluation of the interconversion parameters between diastereomers (k, ΔGT*) was attempted. - - - tubulin / phenylpyrrole / atropisomers / chiral shift reagents

Phenylpyrrolic compounds used as drugs, their preparation and application

The present invention relates to phenylpyrrole compounds, pharmaceutical compositions, preparation and to their application as an active principle, especially as a drug having antimitotic activity.