E-permethylated isogomphidic acid

Base Information

Chemical Name:E-permethylated isogomphidic acid
CAS No.:104206-37-3
Molecular Formula:C₂₄H₂₄O₉
Molecular Weight:456.449
Hs Code.:

Synonyms:E-permethylated isogomphidic acid

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Chemical Property of E-permethylated isogomphidic acid

Chemical Property:

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Technology Process of E-permethylated isogomphidic acid

There total 13 articles about E-permethylated isogomphidic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 849100-15-8
(3-methoxy-5-oxo-4-trifluoromethanesulfonyloxy-5H-furan-2-ylidene)-(3,4,5-trimethoxy-phenyl)-acetic acid methyl ester

: 5720-07-0
4-methoxyphenylboronic acid

: 104206-37-3
E-permethylated isogomphidic acid

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; for 4h; Heating;
DOI:10.1016/j.tet.2004.12.048

Reference yield:

: 2989-06-2
methyl 2-(3,4,5-trimethoxyphenyl)acetate

: 104206-37-3
E-permethylated isogomphidic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 62 percent / tetrahydrofuran / 12 h / -78 - 20 °C

2.1: 72 percent / triethylamine / benzene / 72 h / 20 °C

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: 96 percent / tetrahydrofuran / 12 h / -78 - 20 °C

4.1: 61 percent / Me₃SiOTf / CH₂Cl₂ / 14 h / -78 - 20 °C

5.1: 74 percent / pyridine / CH₂Cl₂ / 4 h / -78 - -10 °C

6.1: 73 percent / potassium phosphate; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dioxane / 4 h / Heating

With pyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl trifluoromethanesulfonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; benzene; 6.1: Suzuki reaction;
DOI:10.1016/j.tet.2004.12.048

Reference yield:

: 849100-06-7
4-methoxy-3-oxo-2-(3,4,5-trimethoxy-phenyl)-butyric acid methyl ester

: 104206-37-3
E-permethylated isogomphidic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 72 percent / triethylamine / benzene / 72 h / 20 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 96 percent / tetrahydrofuran / 12 h / -78 - 20 °C

3.1: 61 percent / Me₃SiOTf / CH₂Cl₂ / 14 h / -78 - 20 °C

4.1: 74 percent / pyridine / CH₂Cl₂ / 4 h / -78 - -10 °C

5.1: 73 percent / potassium phosphate; tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dioxane / 4 h / Heating

With pyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl trifluoromethanesulfonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; benzene; 5.1: Suzuki reaction;
DOI:10.1016/j.tet.2004.12.048