4-(3-nitrophenyl)-2-phenyl-6-trifluoromethyl-5-pyrimidinecarboxylic acid

Base Information

Chemical Name:4-(3-nitrophenyl)-2-phenyl-6-trifluoromethyl-5-pyrimidinecarboxylic acid
CAS No.:103311-85-9
Molecular Formula:C₁₈H₁₀F₃N₃O₄
Molecular Weight:389.29
Hs Code.:

Synonyms:4-(3-nitrophenyl)-2-phenyl-6-trifluoromethyl-5-pyrimidinecarboxylic acid

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Chemical Property of 4-(3-nitrophenyl)-2-phenyl-6-trifluoromethyl-5-pyrimidinecarboxylic acid

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Technology Process of 4-(3-nitrophenyl)-2-phenyl-6-trifluoromethyl-5-pyrimidinecarboxylic acid

There total 6 articles about 4-(3-nitrophenyl)-2-phenyl-6-trifluoromethyl-5-pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.3%

: 103311-97-3
methyl 4-(3-nitrophenyl)-2-phenyl-6-trifluoromethyl-5-pyrimidinecarboxylate

: 103311-85-9
4-(3-nitrophenyl)-2-phenyl-6-trifluoromethyl-5-pyrimidinecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; for 10h; Heating;
DOI:10.1248/cpb.40.2423

Reference yield:

: 1670-14-0
benzamidine monohydrochloride

: 103311-85-9
4-(3-nitrophenyl)-2-phenyl-6-trifluoromethyl-5-pyrimidinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / butan-1-ol / 4 h / Heating

2: MnO₂ / CHCl₃ / 2 h / Heating

3: 80.3 percent / aq. NaOH / methanol / 10 h / Heating

With manganese(IV) oxide; sodium hydroxide; triethylamine; In methanol; chloroform; butan-1-ol;
DOI:10.1248/cpb.40.2423

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 103311-85-9
4-(3-nitrophenyl)-2-phenyl-6-trifluoromethyl-5-pyrimidinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine, acetic acid / benzene / 1 h / Heating

2: Et₃N / butan-1-ol / 4 h / Heating

3: MnO₂ / CHCl₃ / 2 h / Heating

4: 80.3 percent / aq. NaOH / methanol / 10 h / Heating

With piperidine; manganese(IV) oxide; sodium hydroxide; acetic acid; triethylamine; In methanol; chloroform; butan-1-ol; benzene;
DOI:10.1248/cpb.40.2423